THE MICROBIOLOGICAL QUALITY CONTROL OF SOME EXPECTORANT SYRUPS FOUND IN THE MARKET
Ahmet AKIN* °, Erkan ERK*
*Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Tandogan, Ankara, TURKEY.
°Corresponding Author

Summary:
Recently, succesful results were obtained about the pharmaceutical preparations that they haven’t been contaminated with pathogenic microorganisms. In spite of this, these products seem to contain microorganisms, since the formation of infections could not be prevented. From this point of view, we have studied 65 expectorant syrups from different manufacturers with different batch numbers for microbiological quality control. These expectorant syrups were made up of 13 different formulations. We tested five different batches from each formulation.
The microbiological quality control of the syrups were carried out according to USP XXI and BP 1980 methods, that were somewhat modified by us. In the 65 expectorant syrups, the results were as follows: In 37 %, aerobic bacteria and in 4.6 %, fungi were found, which exceeds FIB standards. We isolated E.coli (4.6 %) in our three samples; P.vurgaris (3.1 %) in two samples; B.subtilis (1.5 %) in one sample; S.epidermidis (1.5 %) in one sample and C.albicans (4.6 %) in three samples.
We did not isolate Salmonella spp., Shigella spp., Klebsiella spp., Pseudomonas spp. and Streptococcus spp. in any of the samples.

Keywords:
Syrups, Expectorant, Microbiological Quality.