EFFECTS
OF PHYSICAL THERAPY INTERVENTIONS ON PHARMACOKINETIC PARAMETERS
Selma
SAHIN*°, Edibe YAKUT**
*Hacettepe
University, Faculty of Pharmacy, Department of Pharmaceutical
Technology, 06100 Sihhiye, Ankara, TURKEY. ** Hacettepe
University, School of Physical Therapy and Rehabilitation,
06100 Sihhiye, Ankara, TURKEY.
°Corresponding Author
Summary:
Most studies on drugs have been performed in subjects
at rest.However, little is known how the pharmacokinetics
of a drug is influenced by exercise, application of physical
agents and massage.These interventions may produce hemodynamic
and physiological changes that can potentially alter drug
disposition within the body. Physical therapy interventions
seem to have the greatest potential to affect absorption
and distribution of drugs that are administered by transdermal
techniques or by subcutaneous and intramuscular injections
.Therefore, physical therapists should also realize that
medications can have positive therapeutic effects and
adverse side effects that can influence the patient's
response to physical therapy.The aim of this article is
to discuss how phsical therapy interventions can affect
the pharmacokinetics of various medications, and how the
clinical effects of these medications are affected by
altered drug disposition.
Key
words:
Physiotherapy, Exercise, Pharmacokinetics.