INTERACTION
BETWEEN EPIDERMAL GROWTH FACTOR AND PROSTAGLANDINS
Bilge
GÖNÜL*°
*Gazi
University, Faculty of Medicin, Department of Phisyology,
06100 Etiler, Ankara, TURKEY.
°Corresponding Author
Summary:
Comparative analysis of the effect of epidermal growth
factor, receptor functions, and signalling pathways in
normal and neoplastic cells will aid in understanding
the fundamental mechanisms that control cell proliferation.
Epidermal growth factor (EGF) , a polypeptide comprising
53 aminoacids, has been isolated from extracts of the
submandibular gland of male mice. The biological effects
of EGF include stimulation ofmitotic activity and cell
differentiation, inhibition of gastric acid secretion,
stimulation of the proliferation of gastric mucosal cells,
protection of the mucosa against various noxious stimuli
and promotion of healing of corneal and skin lesions.
The probable mode of action of EGF, as well as other growth
factors, may involve endocytosis of the occupied cell
surface receptors and subsequent action within the cell.
Epidermal growth factor stimulates phosphatidyl-inositol
turnover in the cell, a source of diacylglycerol, fatty
acids and arachidonate.
There are many in vivo and in vitro experiments indicating
the relation between epidermal growth factor and prostagladins.
This report will summarize the literature data concerning
the current knowledge of the effect of epidermal growth
factor and its relation with the prostagladins.
The results of in vivo and in vitro studies, including
our own, shows that epidermal growth factor stimulates
the production of prostaglandin E2. Thus these results
support the relation between prostaglandin E2 levels and
the mitotic activities of epidermal growth factor on different
kinds of cell functions, especially in wound healing and
cancer promotion.
Key
words:
Epidermal Growth Factor (EGF), Prostaglandins, Wound healing.