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FABAD  J. Pharm. Sci.
ISSN 1300-4182
Copyright Ó 2005 FABAD. All rights reserved 

FABAD J. Pharm. Sci., 25(Supplement 1), 35-41, 2000.

Scientific Reviews

ABSTRACT

INTERACTION BETWEEN EPIDERMAL GROWTH FACTOR AND PROSTAGLANDINS

Bilge GÖNÜL*°

*Gazi University, Faculty of Medicin, Department of Phisyology, 06100 Etiler, Ankara, TURKEY.
°Corresponding Author

Summary:
Comparative analysis of the effect of epidermal growth factor, receptor functions, and signalling pathways in normal and neoplastic cells will aid in understanding the fundamental mechanisms that control cell proliferation.
Epidermal growth factor (EGF) , a polypeptide comprising 53 aminoacids, has been isolated from extracts of the submandibular gland of male mice. The biological effects of EGF include stimulation ofmitotic activity and cell differentiation, inhibition of gastric acid secretion, stimulation of the proliferation of gastric mucosal cells, protection of the mucosa against various noxious stimuli and promotion of healing of corneal and skin lesions. The probable mode of action of EGF, as well as other growth factors, may involve endocytosis of the occupied cell surface receptors and subsequent action within the cell. Epidermal growth factor stimulates phosphatidyl-inositol turnover in the cell, a source of diacylglycerol, fatty acids and arachidonate.
There are many in vivo and in vitro experiments indicating the relation between epidermal growth factor and prostagladins. This report will summarize the literature data concerning the current knowledge of the effect of epidermal growth factor and its relation with the prostagladins.
The results of in vivo and in vitro studies, including our own, shows that epidermal growth factor stimulates the production of prostaglandin E2. Thus these results support the relation between prostaglandin E2 levels and the mitotic activities of epidermal growth factor on different kinds of cell functions, especially in wound healing and cancer promotion.

Key words:
Epidermal Growth Factor (EGF), Prostaglandins, Wound healing.