NANOCOCHLEATE - A NEW DRUG DELIVERY SYSYTEM
Thiruganesh RAMASAMY°, Umadevi KHANDASAMY**, Ruttala HINABINDHU*, Kiran KONA*
* Department of Pharmaceutics, Pydah College of Pharmacy, Kakinada, India

* Department of Pharmaceutics, Rao's College of Pharmacy, Kakinada, India

^oCorresponding Author

Summary

This article focuses on the therapeutic potential of a new classs of drug carrier called nanocochleate. This article highlights various methods of preparation for cochleate system. All the preparation method comprises using the charge ratio between the bridging agents and lipids to control the particle size. This cochleate or nano-cochleate system may be used for microencapsulation and delivery of therapeutics, wherein the therapeutics, wherein the therapeutics agents are loaded in the cochleate structure as the bridging agents between lipid bilayers. Finally, this article discusses the advantages, materials used, stability issues and other uses of these new nano-cochleate systems. The properties that nano-cochleate can facilitate cross-membrane diffusion for charged and impermeable molecules finds wide application in drug delivery. Many therapeutic agents, such as peptides, are soluble but impermeable to tissue membranes. Cross-membrane permeation is especially important for those agents for which the binding sites are found inside the cells rather than on cell surface receptors. The system may also facilitate oral absorption for peptide drugs that possess a net positive charge. ın a whole nanocochleate system increases the bioavailability, and hence the therapeutic action of drugs.
 
Key Words :
Cochleate, nanocochleates, liposomesi phospholipid, peptides.