Bioavailability File: OMEPRAZOLE

S. BOZDAG*, S. ÇALIS*°, M.SUMNU*

* Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Sihhiye, Ankara, TURKEY.
°Corresponding Author

Summary:
Omeprazole, îhe selective inhibitor of gastric mucosal proton pump is a substituted benzimidazole derivative. It strongly inhibits the acid secretion of the stomach and is frequently utilized in ulcers of stomach and duodenum, reflux oesophagitis and Zollinger Ellison Syndrome. Omeprazole is very sensitive to moisture, heat and pH changes, thus not stable in acidic solution and degrades rapidly. The physicochemical and pharmacological properties, pharmacokinetics and bioavailability of omeprazole are discussed in this review.

Key words:
Omeprazole, Ulcers of Stomach and Duodenum, Zollinger Ellison Syndrome, Stability, Bioavailability, Pharmacokinetic.