N.Nehir GÜLERMAN*, Sevim ROLLAS*o, Habibe ERDENİZ**, Muammer KİRAZ**

*Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 81010, Haydarpasa, Istanbul, TURKEY.
** Istanbul University, Faculty of Medicine, Center For Research and Aplication of Culture Collections of Microorganisms, 34452, Çapa, Istanbul, TURKEY.
oCorrespondence

Summary:
In this research, some 1-[4-(acetylamino)benzoly]-4-subsituted thiosemicarbazides and 5-[4-(acetylamino)phenyl]-2-subsitutedamino-1,3,4-thiadiazoles were screened for antibacterial, antifungal and antiycobacterial activites. The minimum inhibition concentration(MIC) values of compounds have been determined using the microdulition methood and the BACTEC 460 radiometric system. Some of the compounds were found to be active against Mycobacterium fortuitum strain and 5-[4-(acetylamino)phenly]-2-ethylamino-1,3,4-thiadiazole showed a MIC value (16microgram/mL) equivalent to that of tobramycin, which was used as the standart compound.