BIOAVAILABILITY FILE: FLUVOXAMINE

Nursin GÖNÜL*°, Rahmiye ERTAN**, Oya BOZDAG-DÜNDAR**

*Ankara Üniversitesi, Eczacilik Fakültesi, Farmasötik Teknoloji Anabilim Dali, 06100 Tandogan, ANKARA
**Ankara Üniversitesi, Eczacilik Fakültesi, Farmasötik Kimya Anabilim Dali, 06100 Tandogan, ANKARA
°Correspondence

Summary:
Fluvoxamine, which specifically inhibits the serotonin reuptake, is an antidepressant compound from the series of 2-aminoethyloximethers of arylalkylketones, which is a newly developed and second generation antidepressant class. It is used in the treatment of psychiatric disorders such as depression, obsessive-compulsive and panic; aggression and posttraumatic stress disorders, bulimia and recently alcohol and drug abuse. In this article the physicochemical properties, assay methods, pharmacological properties, pharmacokinetics and bioavailability of fluvoxamine and drug interactions are outlined.

Key words:
Fluvoxamine, Fluvoxamine maleate, Antidepressant, Pharmacokinetics, Bioavailability.