E. Öykü ÇETIN*, Selma ŞAHİN*?, A.Atilla HINCAL*

*Hacettepe Üniversitesi, Eczacilik Fakültesi, Farmasötik Teknoloji Anabilim Dali, 06100, Sihhiye, Ankara, TÜRKIYE.
° Correspondence

Summary:
Despite its side effects, chlorpromazine has been a widely used phenothiazine derivative in the treatment of schizophrenia and related disorders.In addition to psychiatric disorders, it has also been used as an antiemetic, anticholinergic and antipruritic agent. After oral administration, the percentage of chlorpromazine reaching to the systemic circulation is very low and dose dependent. Due to extensive first pass metabolism, intra-subject and inter-subject variances are very high. In this review, physicochemical and pharmacological properties, pharmacokinetics and bioavailability of chlorpromazine are discussed.

Keywords:
Chlorpromazine, Pharmacokinetics, Bioavailability, Pharmacology, Drug interactions.