Meral ÖZALP*, Ünsal ÇALIŞ**, Nesrin GÖKHAN**, Hakkı ERDOĞAN**

*Hacettepe Universty, Faculty of Pharmasy, Pharmacetical Microbiology Depertment, 06100 Ankara-TURKEY
**Hacettepe University, Faculty of Pharmacy, Pharmaceutial Chemistry Departmant, 06100 Ankara-TURKEY

Summary:
In this study,six 3-methyl-6-(2-substitued aminopropanoly)-2-benzoxazolinones and their reduction products were screened for their antibacterial and antifungal activities.The minimum inhibition concentration(MIC)values of the compounds were determined by the broth microdilution method using two Gram positive(Staphyiococcus areus ATCC 25923, Enterococcus faecalis ATCC 29212),two Gram negative(Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853)bacteria and yeast-like fungi Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019).None of the compounds were found to be active against both Gram positive and Gram negative bacteria.3-methyl-6-(1-hydroxy-2-morpholinopropyl)-2-benzoxazolinone (Compound III)which possesses remarkable activity againts Candida krusei was found to be the most active compound in this serices.

Key words:
2-benzoxazolinone,antimicrobial activty,antibacterial and antifungal activities,in vitro studies.