THE CHARACTERISTIC OF TRANSFORMING GROWTH FACTOR ALPHA AND ITS EFFECTS ON THE CANCER CELLS AND ULCER CELLS AND ULCER WOUNDS

Gülay Yetkin*, Nevin Çelebi*°

*Gazi üniversitesi, Eczacilik Fakültesi, Farmasotik Teknoloji Anabilim Dali, 06330 Etiler-Ankara
° Correspondence

Summary:
Transforming growth factor alpha(TGF?) is a single chain polypeptide containing 50 aminoacids which was first detected in the conditioned medium of murine 3T3 fibroblasts transformed with the Moloney murine sarcoma virus.TGF? is a mitogenic polypeptide that inhibits gactric acid secretion,protects the gastric mucosa aganist acute injury and accelerates ulcer healing.Also TGF? plays important roles in wound healing in tissues such as cornea and skin.But its role in neoplastic development is still unclear.The levels of TGF? in many tissues were thought to be quite low,but recents observations on self renewing epithelial tissues(e.g. skin and gastrointestinal tract) have detected significant concentrations of TGF?.The discovery,initial characterization,in vivo activity,in vitro activity of TGF? and acterization,in vivo activity,in vitro activity of TGF? and the effects of its on the healing of gastric ulcers and cancer the effects of its on the healing of gastric ulcers and cancer will be discussed in this review.

Key words:
Transforming Growth Factor Alpha, Wound Healing, Gastric Ulcer,Cancer, Antitumor.