THE PROTECTIVE EFFECTS OF CINNARIZINE AND NITRENDIPINE ON NAPHTALENE INDUCED OXIDATIVE STRESS IN MICE TISSUES

Şebnem Ş ÇEÇEN*, Gülhan CENGİZ*, Göknur AKTAY**, Tülin SÖYLEMEZOĞLU*,o

*Ankara University, Institute of Forensic Medicine, 06260 Dikimevi, Ankara, TURKEY.
**Inönü University, Faculty of Pharmacy, Department of Pharmacology, Malatya, TURKEY.
°Corresponding author

Summary:
In this study, the effects of nitrendipine and cinnarizine, dihydropyridine and diphenylpiperazine derivative calcium channel antagonists, respectively, on naphtalene-induced oxidative stress were investigated in mice. Nitrendipine (NIT; 50 mg/kg,i.p.) , cinnerazine (CIN; 200mg/kg, i.p.) were administrated one hour prior to the administration of naphthalene (NAP; 400 mg/kg, i.p.). lactate dehydrogenase (LDH) , malondialdehyde (MDA) and cellular glutathione (GSH) levels were determined as markers of oxidative stress. As a result, the two different derivatives of calcium antagonists, nitrendipine and cinnarizine may have different functions against NAP-induced toxicity depending upon the organo-specifity.

Key words:
Naphtalene, Oxidative stress, N-Acetylcysteine, Nitrendipine, Cinnarizine.