Zeliha Ş. AKDEMİR *,o, İ. İrem TATLI*, Erdal BEDİR**,***, Ikhlas A. KHAN **

* Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Sıhhiye, Ankara, TURKEY.
** National Center for Natural Products Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississppi 38677,USA
*** Ege University, Faculty of Engineering, Department of bioengineering, 35100 Bornova, İzmir, TURKEY.
oCorresponding Author e-mail:zakdemir@hacettepe.edu.tr

Summary:
The antimicrobial activities of ethyl acetate and methanol extracts of five Verbascum species were studied. The dried extracts of the aerial parts of Verbascum chionophyllum Hub.-Mor., V. cilicicum Boiss., V.pterocalycinum var.mutense Hub.-Mor., V. pycnostachyum Boiss & Helder. and V. splendium Boiss. were tested in vitro against Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 90113), Staphylococcus aureus (ATCC 29213), methicillinresistant S. aureus (ATCC 43300), Pseudomonas aeruginosa (ATCC 27853), Aspergillus fumigatus (ATCC 90906) and Mycobacterium intracellulare (ATCC 23068) using a 96-well microplate assay. Amphotericin B, ciprofloxacin and rifampin were used as positive controls. The antimalarial activities of the same extracts were also tested to Plasmodium falciparum clone [Sierra Leone D6 (chloroquine-sensitive)]. The antimalarial agents chloroquine and artemisinin were used as positive controls. None of the tested extacts showed important antimicrobial or antimalarial activities.