PREPARATION
OF MELOXICAM TABLET FORMULATIONS AND EVALUATION OF IN VITRO
RELEASE SIMILARITIES
Canan ERYOL*, Esra DEMİRTÜRK*, Levent ÖNER*,o
*Hacettepe University, Faculty of Pharmacy, Department of
Pharmaceutical Thechnology, 06100 Sıhhiye, Ankara, TURKEY.
oCorresponding Author
Summary
Meloxicam is a nonsteroidal-antinflammatory drug, which
inhibits COX-2 enzymes and is practically insoluble in water.
Immediate-release meloxicam tablet formulations were prepared
by wet granulation method and the dissolution profiles of
these formulations were compared with the reference formulation
(Mobic® lot no: 009621). The objective of this study was
to apply several dissolution profile comparison methods
to five different immediate-release meloxicam tablet formulations
and to identify the advantages and disadvantages of each
method. Methods used to compare the dissolution data were,
statistical methods (exploratory data analysis method, repeated
measures design multivariate approach (MANOVA) and ANOVA-based
methods), model dependent methods (zero order, first order,
Hixson-Crowell, Weibull and logistic model) and model independent
methods (difference factor (f1), similarity factor (f2)
and Rescignos indices (?i)).
Key Words :
Meloxicam, dissolution profile comparison methods. |
