Efficiency of Chitosan Film Formulation Following Experimental Brain Edema
Hakan EROĞLU*, Ömer Faruk TÜRKOĞLU**, Özerk OKUTAN**, Oktay GÜRCAN***, Ebru BODUR****, Mustafa F. SARGON*****, Etem  BESKONAKLI**, Levent ÖNER*^,°

* Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Sıhhiye/Ankara, Turkey
** Ankara Atatürk Research and Education Hospital, Department of Neurosurgery, Bilkent/Ankara, Turkey
*** Ankara Numune Research and Education Hospital, Department of Neurosurgery, 06100, Sıhhiye/Ankara, Turkey
**** Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100, Sıhhiye/Ankara, Turkey
***** Hacettepe University, Faculty of Medicine, Department of Anatomy, 06100, S›hhiye/Ankara, Turkey

^oCorresponding Author

Summary

In this study, film formulations containing dexamethasone sodium phosphate were prepared by using a natural polymer chitosan. The in vivo efficiency of film formulations were evaluated by the animal model in which the brain edema was formed on Sprague Dawley rats. The evaluation of the efficiency for film formulations were investigated through the parameters such as wet-dry weight method, determination of the lipid peroxidation ratio, ultrastructural grading system and Transmission Electron Microscopy. The statistical evaluation of te experimental results revealed no significant difference between the experimental groups (p>0.05) which is probably due to the insufficient release medium in the craniectomy area, the movements of the film formulation as a result of the natural movements of the animals after surgery.

Key Words :
Chitosan, Dexamethasone Sodium Phosphate, Film,cold Injury, Brain Edema