Antimicrobial Activity of Ferula halophila Peflmen
Ayşe BALDEMİR*, Maksut COŞKUN*^,°, Sulhiye YILDIZ**
* Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 06100, Tandogan-Ankara, TURKEY
** Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06100, Tandogan-Ankara, TURKEY
 

^oCorresponding Author

Summary

Water, methanol extract and fractions obtained from methanol extract (chloroform, ethyl acetate, butanol and remainder) of the aerial and underground parts of Ferula halophila were evaluated for antimicrobial activities. Cefazolin, ciprofloxacin and fluconazole were used as standards. Antimicrobial activities of the extracts against Staphylococcus aureus ATCC 25923, Methicillin-resistant Staphylococcus aureus (MRSA) (clinical isolate), Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Bacillus cereus RSKK 1122, Bacillus subtilis ATCC 6633, Enterococcus faecalis ATCC 29212 and Candida albicans ATCC 10231 were investigated by using disc diffusion method. It was observed that the chloroform extract of aerial and underground parts showed activity against Gram-positive MRSA, S. aureus, B. cereus, and B. subtilis. While the extracts of the aerial parts showed less effect. None of the extracts was found active against the Gram-negative bacteria E. coli and P. aeruginosa or against the Gram-positive
bacterium E. faecalis. Similarly, extracts of aerial and underground parts had no antifungal activity against C. albicans. The activity of the extracts and fractions of aerial and underground parts of Ferula halophila was less than that of the standards.

Key Words :
Ferula halophila, Umbelliferae, antimicrobial, activity