BIOAVAILABILITY FILE: GLIPIZIDE
Mustafa Sinan KAYNAK*, Levent ÖNER*,o
*
Hacettepe University, Faculty of Pharmacy, Department of
Pharmaceutical Technology, 06100, Sýhhiye, Ankara, TURKEY
oCorresponding Author
Summary
Glipizide is a member of the second-generation sulfonylurea
drugs used in the treatment of type 2 diabetes mellitus. It
is completely absorbed from the gastrointestinal tract and
metabolized into five different metabolites in the liver,
and does not show the hypoglycemic activity by itself. It
exhibits its hypoglycemic activity through pancreatic and
extrapancreatic pathways. Glipizide is 98% bound to plasma
proteins and has a half-life between 2.5 and 4.7 hours.
Cimetidine and ranitidine increase the plasma concentration
of Glipizide approximately three times. On the other hand,
active charcoal may decrease the absorption of Glipizide. No
effect of age or obesity exists on the absorption and
bioavailability of Glipizide. In this paper, the
physicochemical and pharmacological properties,
determination methods and pharmacokinetics of Glipizide are
reviewed.
Key Words :
Glipizide, NIDDM, type II diabetes,
pharmacokinetics, bioavailability
