Spectrofluorometric Determination of Citalopram HBr in Tablets
H. Eda ŞATANA*,^o, Nusret ERTAŞ*, Nilgün Günden GÖĞER*
* Gazi University, Faculty of Pharmacy, Department of Analytical Chemistry, Etiler - Ankara, Turkey

^oCorresponding Author

Summary

Citalopram is a selective serotonin reuptake inhibitor that is used for the treatment of depression. A rapid, selective, sensitive, and simple fluorescence method has been developed for the direct determination of citalopram in pharmaceutical tablets. Standard citalopram and the tablets were dissolved in distilled water and excited at 240 nm, and fluorescence emission intensity was measured at 300 nm. Calibration curve was linear between 5.0x10-7 - 2.5x10-6 M citalopram. LOD and LOQ values were found as 8.0x10-9 and 2.6x10-8 M citalopram, respectively. The method has been applied for the determination of citalopram in tablets, and no interference effect was observed from excipients. Recovery values were in the range of 100.5-101.3%. The proposed method was compared with UV-VIS spectrophotometric method and it was found that there was no statistically significant difference between the two methods in terms of accuracy and precision.

Key Words :
Citalopram, spectrofluorometry, pharmaceutical tablets