Evaluation Of Antimicrobial Activities of Some 2(3h)-Benzoxazolone Derivatives
 Zeynep SOYER*^,°, Bayri ERAÇ**
 * Ege University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 35100 İzmir TURKEY
** Ege University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 35100 İzmir TURKEY

° Corresponding author E-mail: zeynep.soyer@ege.edu.tr

Summary

In this study, 12 ω-(2-oxo-2-benzoxazoline-3-yl)-N-phenylacetamide and propionamide derivatives bearing substituents with different lipophilic and electronic nature on N-phenyl ring were tested for antimicrobial activity. For this purpose, minimal effective concentrations of the compounds were determined against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by using microdilution method. The results demonstrated that 3-(2-oxo-2-benzoxazoline-3-yl)-N-(m-tolyl)propionamide derivative was the most active compound in the series against Escherichiacoli, Staphylococcus aureus and Enterococcus faecalis.

Key Words :
Antimicrobial activity, 2(3H)-Benzoxazolone, amide, synthesis Erica arborea, Erica manipuliflora, Erica bocquetii, Erica sicula subsp. libanotica, trace elements.