In vitro Cytotoxic Activities of Platinum(II) Complexes Containing 2-Acetoxymethyl and 2-(2’-Hydroxyethyl)benzimidazole Ligands
Gökçen EREN*, Fatma GÜMÜŞ*^,°, Şükran YILMAZ**
* Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
** Cell and Virus Bank Department, Foot and Mouth Disease Institute, Ankara, Turkey

° Corresponding Author E-mail: fgumus@gazi.edu.tr

Summary

Two platinum(II) complexes with the structures [PtL2Cl2] (L=2-acetoxymethyl (1) and 2-(2’-hydroxyethyl) (2) benzimidazole as carrier ligands) were evaluated for their in vitro cytotoxic activities against the human MCF-7 breast (Estrogen receptor (+), ER(+)), MDA-MB-231 breast (Estrogen receptor (-), ER(-)), Caco-2 colon, and SK-Hep-1 liver cancer cell lines. The biological studies have shown that Compound 1 which has more lipophylic group on the second position of its benzimidazole ligand is more active than compound 2 and the complexes tested have found to be more active against MDAMB-231 (ER(-)) cell line than MCF-7 (ER(+)) cell lines.

Key Words :
Benzimidazole, cytotoxic activity, MCF-7, MDA-MB-231, platinum complexes.