Synthesis and Analgesic, Antiinflammatory and Antimicrobial Evaluation of 6-Substituted-3(2H)- Pyridazinone-2-acetyl-2- (Substituted Benzal) Hydrazone Derivatives
Zeynep ÖZDEMİR*, Mehtap GÖKÇE°**, Arzu KARAKURT*

* İnönü University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 44280, Malatya, Turkey
** Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06330, Ankara, Turkey
° Corresponding Author E-mail: mgokce99@gmail.com,

Summary

In present study a series of new 6-substituted-3(2H)- pyridazinone-2-acetyl-2- (substituted benzal) hydrazone derivatives were synthesized and evaluated for analgesic, and anti-inflammatory and antimicrobial activities. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. Analgesic activity of new pyridazinone derivatives have been tested by the phenylbenzoquinone-induced writhing test (PBQ test), and anti-inflammatory activity have been evaluated the carragenan-induced paw edema method. A significant dependence of the anti-inflammatory and analgesic effects on the substituents has been observed. The pharmacological study of these compounds confirms that modification of the atom or chemical group at phenyl ring of benzalhydrazon moiety influences analgesic and antiinflammatory activities. Synthesized compounds have been shown moderate antimicrobial activities.

Key Words :
6-Substituted-3 (2H) -pyridazinones, Benzaldehyde Hydrazones, Analgesic activity, Antiinflammatory activity.