Preparation of Chitosan Nanoparticles by Nano
Spray Drying Technology
Gulen Melike DEMIR*°, Ismail Tuncer DEGIM**
* Gazi University, Faculty of Pharmacy, 06330, Ankara, TURKEY
** Biruni University, Faculty of Pharmacy, 34010, Ýstanbul, TURKEY
°Corresponding Author:
Phone: +90 (312) 202 3058
Fax: +90 (312) 202 7958
e-mail: gulenmelikedemir@gmail.com
SUMMARY
Spray drying is a fast, continuous process, leading to transform of
a liquid feed into dry particles. This process is completed in three
steps; the atomisation, the mixing of fine droplets with gas stream and
the separation and collection of dried powder. Besides, nano-spray
technology is a breakthrough innovation in order to obtain submicron
particles from a solution. Particle size is a one of the indicator of
product quality and performance. The main aim of this study was
to determine critical process parameters of nano-spray dryer and
to evaluate the effects of these parameters on particle characteristics
and operation capacity. Nano-spray dryer B-90 was used. In terms
of manufacturing process, orifice, spray capacity and polymer
concentration were chosen as critical process parameters and their
effects on product characteristics as particle size and polydispersity
index and zeta potential were evaluated. Moreover, their effects
on operation capacity as product yield and process yield were also
evaluated. Process yield was calculated as sprayed sample volume per
unit process time. Chitosan was chosen as a model polymer with the
concentration of 10 and 20% (w/v). According to results of particle
characteristics and operation capacity, smaller orifice leads smaller
particle size for final product but lower operation capacity. On
the other hand, the sprayed volume showed linear proportion with
operational capacity but no effect on particle size. Increased polymer
concentration improved the yield of dry powder and showed more
positive zeta potentials as it exhibited decreased operation capacity
Key Words:Spray dryer, chitosan, nanoparticle, nano-spray dryer
B-90
