Big Effects of Low Dose Bisphenol A

Beyza AYAZGÖK*º, Tuba TÜYLÜ KÜÇÜKKILINÇ*

* Hacettepe Üniversitesi Eczacılık Fakültesi Biyokimya Anabilim Dalı

ºCorresponding Author:
Phone: 312 305 14 99
Fax: 312 311477
E-mail: beyza.ayazgok@hacettepe.edu.tr

 

Summary

Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane) polycarbonate is an industrial component frequently used as an additive in the construction of epoxy resin and other non-polymer plastics. BPA has been described as an endocrine disrupting chemical (EDC) because it has been shown to be estrogenic activity in most studies. The widespread use of BPA in the plastics industry causes intensive dispersion and inevitable human exposure to the environment. BPA has been shown to effects physiological functions of cells and tissues by binding to nuclear receptors even at low concentrations. It is also known that BPA interacts with thyroid hormone receptors, androgen receptors, peroxisome proliferator activated receptors, and other endocrine system receptors. It is also stated that BPA has effects on central nervous and immune systems. BPA exposure has been reported to have adverse effects on the cardiovascular system, respiratory system, and renal system, and may cause birth defects and breast cancer. The issue of restriction and prohibition of BPA usage due to many adverse effects, has been addressed by the scientific community and health authorities. National Toxicology Program (NTP) shared with publicy their concerns about the effects of BPA exposure in the fetus, adults and children on brain, behavior and fertility at report published in 2008. In 2010, the United States Food and Drug Administration (FDA) reported the same concerns with NTP. Parallel to the decision of the European Commission to limit use of BPA in the production of bottled water, Bottles containing bpa and other nutrition supplies were collected in our country by the Ministry of Agriculture and the Ministry of Health in June 2011. Considering that BPA may have chronic effects at low doses, scientific studies continue to understand and avoid other possible adverse effects.

Key Words :
Endocrin Disruptors, Bisphenol A, Estrogen, BPA Exposure, Low Dose BPA, Chronic Effects of BPA.