Gebelikte Tiroid Fonksiyon Bozukluğunda Kullanılan İlaçlar ve Toksisiteleri

Esra TEL* ve Suna SABUNCUOĞLU *°

* Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı Sıhhiye, 06100, Ankara, Türkiye

° Corresponding Author;
Tel: + 90 312 305 21 78,
Faks : + 90 312 311 47 77,
E-mail: sunaatasayar@gmail.com

 

Summary

Pregnancy is a physiological process between fertilization and birth, which involves changes that take place in line with the needs of the developing fetus. The use of medicines may be due to preexisting pregnancy or diseases that occur during pregnancy. Thyroid dysfunctions are also included in these diseases. Thyroid dysfunction is seen in approximately 2-3% of pregnancies. If it is not treated, it can cause serious risks to both mother and baby. Although the drugs used in the treatment of these disorders are generally safe, some of derivatives can cause side effects for mother such aagranulocytosis, thrombocytopenia, tachycardia, nephrotic syndrome. Again depending on the use of medicines; teratogenic effects such as fetal hyperthyroidism / hypothyroidism, neonatal head development disorders can be observed by antibody or drug transfer from placenta to baby. As in each drug group, thyroid drugs must be used only after the benefit / benefit ratio is well assessed. In this review, teratogenic potentials of drugs used in thyroid function disorders during pregnancy are evaluated.

Key Words :
Pregnancy, fetus, thyroid disorders, thyroid drugs, teratogenicity, toxicity