EFFECT OF GEONETICS ON THE BIOAVAILABILITY AND DISPOSITION KINETICS OF MEFENAMIC ASID

Nadeem Irfan BUKHARI*°, Mahmood Ahmad*, Shadab QAMAR**

* Islamia University, Department of Pharmacy, Bahawalpur-Pakistan.
**Pakistan Council for Scientific and Industrial Research (PCSIR) Laboratories, Lahore Pakistan.
°Corresponding Author

Summary:
The effect of geonetics on the pharmacokinetic behavior of mefenamic acid after an oral administration of drug was studied in 27 healty rabbits. Mefeamic acid was estimated by high performace liquid chromatography. The Cmax of 3.36 ? 0.55 ?g/mL was attained within 2.5 hours. The values for AUC0-? and MRT of the drug were noted to be 14.9 ? 2.02 ?g.hr/mL and 4.16 ? 0.26 hours, respectively. Elimination half-life, volume of distribution and total body clearance were observed to be 1.93 ? 0.29 hrs, 14.5 ? 2.58 L and 86.6 ? 9.67 mL/min., respectively. Remarkable variations were noted when the present findings were compared with the respective values cited in the literature. Inadequate studies on the pharmacokinetics of mefenamic acid made it difficult to conclude that geonetics is the only basis of these variations. The other variation factors may include differences in study design, subject selection, drug dose, dosage forms, routes of administration, analytical methods and species difference. The use of various pharmacokinetic computational techniques and pharmacokinetic software may also be the variation determinant.

Key words:
Pharmacokinetics, Bioavailability, Geonetics, Mefenamic acid, Pharmacokinetic Softwares.