IRIDOID GLUCOSIDES FROM SIDERITIS LYCIA BOISS. & HELDR.AND ITS ANTIMICROBIAL ACTIVITES

Yelda AKCOS*, Nurten EZER**°, Berrin ÖZÇELIK***, Ufuk ABBASOGLU***

*Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, TURKEY.
**Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 06100, Ankara, TURKEY.
***Gazi University, Faculty of Pharmacy, Department of Microbiology, 06330, Ankara, TURKEY.
°Corresponding Author

Summary:
Two iridoid glucosides;ajugol and ajugoside were isolated from the aerial parts of Sideritis lycia Boiss.&Heldr. The structural elucidation of these compounds were achieved by chemical (UV,IR,1H and 13C-NMR).Antimicrobial activity of ajugol was investigated by microdilution method. Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25882, Pseudomonas aeruginosa RSKK 356 were used as bacteria and Candida albicans ATCC 64550 and Cryptococcus neoformans as yeastlike fungi.

Key words:
Sideritis Iycia, Lamiaceae, Iridoid Glucoside, Antibacterial Activity, Antifungal Activity.