IN VITRO ANTIMICROBIAL ACTIVITIES OF SOME 5(6)-SUBSTITUTED-2-HIDROXYMETHYLBENZIMIDAZOLES AND THEIR PLATINUM (II) COMPLEXES

Öztekin ALGÜL*, Ufuk ABBASOGLU**, Fatma GÜMÜS*°

*Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06330 Etiler, Ankara, TURKEY.
** Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06330 Etiler, Ankara, TURKEY.
°Corresponding Author

Summary:
In this study, in order to evaluate the in vitro antimicrobial activity differences of the ligands and their Pt(II) complexes, and the role of the coordination metal ion, in vitro antimicrobial activities of some 5(6)-non/ or chloro/ or methyl substituted-2-hydroxymethylbenzimidazoles and their Pt(II)complexes were tested against some gram-positive and gram-negative bacteria and yeast like fungi. The test results have shown that most of the compounds tested had MIC values of 50 µg/ml against the microorganisms used and the poor antibacterial and antifungal activities of the compounds cannot be considered noteworthy. A comparative study of the MIC values indicated that,in general,there were no reasonable differences between the in vitro antimicrobial activity values of the ligands and their Pt(II) comlexes against the tested microorganisms.

Key words:
2-Hydroxymethylbenzimidazole, Platinum(II) complexes, In vitro antimicrobial activities.