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FABAD
J. Pharm. Sci.
ISSN 1300-4182
Copyright Ó 2005
FABAD. All rights reserved
FABAD
J. Pharm. Sci., 26(3), 113-117, 2001.
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Research
Articles
ABSTRACT
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SYNTHESIS
AND ANTIMICROBIAL ACTIVITIES OF SOME SUBSTITUTED THIOSEMICARBAZIDES,1,2,4-TRIAZOLE-5-THIONES
AND THEIR 5-METHYL DERIVATIVES
Erhan
PALASKA* , Gülay SAHİN* , Melike EKİZOĞLU** , Meral
ÖZALP**
*Hacettepe
University,Faculty of Pharmacy,Department of Pharmaceutical
Chemistry, o6100 Ankara,TURKEY
**Hacettepe University,Faculty of Pharmacy,Department
of Pharmaceutical Microbiology, o6100 Ankara,TURKEY
Summary:
A series of new 1- [(1-naphthly)oxyacetyl]-4-substituted-thiosemicarbazides,
3-[(1-napthyl)oxymethyl]-4-substituted-1,2,4-triazole-5-thiones
and 3-[(napthyl)oxymrthyl]-4-substituted-5-methylmercapto-1,2,4-triazoles
have been synthesized from 1-napthol.The chemical structures
of the compuonds were proved by IR, 1H-NMR and elementary
analysis.Antimicrobial activities of the synthesized compounds
were investigated against Staphylococcus aures, Enterococcus
faecalis, Escherichia coli and Pseudomonas aeruginosa,
Candida albicans, C.krusei and C. parapsilosis by the
microdilution method..
Keyword:
Thiosemicarbazide 1,2,4-Triazole-5-thione, 5-Methylmercapto-1,2,4-triazole,
Antifungal Activity, Antibacterial Activity.
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