SYNTHESIS OF SOME NEW AMINOALKYLGUANIDINE DERIVATIVES AND
THEIR IN VITRO ANTIMICROBIAL ACTIVITIES

Ünsal ÇALIS*º, Meriç KÖKSAL*, Meral ÖZALP**

*Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry,06100 Ankara-TURKEY
**Hacettepe University ,Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06100 Ankara-TURKEY

Summary:
In this study, the antimicrobial activities of seven compounds of aminoalkylguanidine derivatives were tested. Five of these compounds (Compound 1-5) were synthesized previously. Two of the compounds included in this study to evaluate antimicrobial efficiency (Compound 6,7 ) were synthesized originally by the reaction of S-methylthiourea and appropriate amines. The structures of these two compounds were confirmed by IR, 1H-NMR and elementary analysis. The antimicrobial activity of all of the compounds was investigated by broth microdilution method by using two Gram positive (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212) and two Gram negative (Escherichia coli ATCC 25922 , Pseudomonas aeruginosa ATCC 27853 ) bacteria and yest-like fungi (Candida albicans ATCC 90028 , Candida krusei ATCC 6258,Candida parapsilosis ATCC 22019). Among the compounds tested N-[3-(2-Adamantylamino)1-propyl]guanidine sulfate showed the most favorable activity.

Key words:
Aminoalkylguanidine, Synthesis, Antimicrobial Activity , Antibacterial Activity, Antifungal Activity