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FABAD
J. Pharm. Sci.
ISSN 1300-4182
Copyright Ó 2005
FABAD. All rights reserved
FABAD
J. Pharm. Sci., 27(1), 27-41, 2002.
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Scientific
Reviews
ABSTRACT
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MICROEMULSIONS:
GENERAL PROPERTIES AND PHARMACEUTICAL APPLICATIONS
Ayse ÇİLEK*, Ali TÜRKYILMAZ**, Nevın ÇELEBİ*,o
*Gazi University, Faculty of Pharmacy, Department of
Pharmaceutical Technology, 06330 Etıler, Ankara, TURKEY.
**İ.E. Ulagay, Davutpaşa Caddesi, No:12,34473, Topkapı,
Istanbul, TURKEY.
oCorresponding Author
Summary:
Recently, much attentıon has been paid to potential pharmaceutical
uses of microemulsions as novel drug delivery systems.
Mıcroemulsions are defıned as microcomponent systems consisting
a unique ratıo of component including a lipophilic phase,
a hydrophylic phase, a surfactant and co-surfactant.The
properties of this systems are low viscosity, transparent,
thermodynamically stable and droplet diameter less than
140 nm. Such systems are formed spontaneously. Microemulsions
are potential drug carrier systems for oral, topical and
parenteral administration. Especially, these dosage forms
have been recently suggested as carriers for peroral peptide
drugs. The use of microemulsions as possible therapeutic
system is interesting for controlled drug release and
increased systemic and topical absorption of drugs. The
structure and characteristics of microemulsion and the
use of these systems in pharmaceutical field will be discussed
in this review.
Key
words:
Microemulsion, Phase diagram, Pharmaceutical applications
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