FORMULATION
AND EVALUATION OF SALBUTAMOL SULPHATE TABLETS PREPARED BY
DIRECT COMPRESSION USING VARIOUS EXCIPIENTS: STATISTICAL
COMPARISON OF DISSOLUTION METHODS AND TABLET PROPERTIES
Mine
ÖZYAZICI*, Ferhan SEVGÝ*,o
*Ege
Universty, Faculty of Pharmacy, Department of Pharmaceutical
Technology, 35100 Bornova, Ýzmir-TURKEY.
oCorresponding Author
Summary
:
The tablet formulation of salbutamol sulphate (SBS), which
is an antiasthmatic drug, was studied. It was aimed to
investigate the effect of some excipients such as insoluble
fillers and different disintegrants on the physical properties
of salbutamol sulphate tablet formulations in this study.
Meanwhile, the physical parameters and in vitro dissolution
rates of SBS tablet avalaible on the Turkish drug market
were also investigated. Apparatus 1 and II (USP XXIV)
in the dissolution test and UV spectrophotometric method
were used for the assay of the active substance.
Paddle and basket dissolution test results were evaluated
with DUNCAN test and a significant difference was found
when compared statistically.
Formulation and Evaluation of Salbutamol Sulphate Tablets
Prepared by Direct Compression Using Various Excipients:
Statistical Comparison of Dissolution Methods and Tablet
Properties
Keywords
:
Salbutamol sulphate tablets, Duncan test, Turkish drug
market, in vitro availability, Rotating basket method,
Paddle method, Kinetic evaluation.
