Ayla BALKAN*,o, Fügen ÖZKANLI*, Oya Ünsal*, Zafer GÖREN**, Berna TERZİOĞLU**

* Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Sıhhiye-Ankara. TURKEY.
** Marmara University, Dept. Of Pharmacology and Clinical Pharmacology, The school of Medicine, İstanbul-TURKEY.
oCorresponding Author

Summary:
In this study, some new 3-oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazine derivatives have been prepared by the reaction of 5-substituted benzylidene-6-methyl-(4H)-pyridazin-3-one with several substituted benzoylmethyl bromides. The structures of the compounds have been elucidated by IR, 1H-NMR and elemental analysis. Antinociceptive (only for compound IIIa) and anti-inflamma-tory activity studies were evaluated by using in vivo tests. The anti-inflammatory activity was studied by means of the "carrageenan paw edema", whereas the "acetic acid writhing" test was used to assess the antinociceptive activity. Qualitatively, compound IIIa was shown to exert anti-inflammatory effect as potent as phenylbutazone and antinociceptive effect similar to acetylsalicylic acid.
Studies on Some 3-Oxo-5-ben-ylidene-6-methyl-(4H)-2-substitutedpyridazines with Antinociceptive and Antiinflammatory activities