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FABAD
J. Pharm. Sci.
ISSN 1300-4182
Copyright Ó 2005
FABAD. All rights reserved
FABAD
J. Pharm. Sci., 29(1), 27-38, 2004. PDF
(157 KB)
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Scientific
Reviews
ABSTRACT
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LARGE RING CYCLODEXTRINS-RECENT
PROGRESS
Tomohiro ENDO*, Haruhisa UEDA*,o
*Hoshi University 4-41, Department of Physical Chemistry,
Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, JAPAN.
oCorresponding Author
Summary
Cyclodextrin (CD) is a common name for cyclic a-1,4-glucans.
Not only the well known ?-, ß- and ?-CDs, which are composed
of six, seven and eight D-glucopyranose units, but also
large-ring CDs (LR-CDs), with more than nine D-glucopyranose
units, exist in the group. LR-CDs were found by French
et al. in the 1960s; however, because of difficulties
in the purification and isolation of LR-CDs, there were
only two papers, written by French et al., before 1985.
After the development of a preparation method for the
mixture of LR-CDs in 1986, studies on LR-CDs started again.
In the last decade, knowledge about the enzymatic production,
physicochemical properties, structural features and inclusion
complex formation abilities of LR-CDs has increased substantially.
In this mini review, recent findings on the production,
physicochemical properties, inclusion complex formation
ability and applications of LR-CDs are discussed and shown.
Key Words :
Cyclodextrin, large-ring cyclodextrin, production, physicochemical
property, inclusion complex formation ability.
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