FABAD J. Pharm. Sci., 29(1), 39-49, 2004.

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FABAD J. Pharm. Sci., 29(1), 39-49, 2004. PDF (91 KB)

Scientific Reviews

ABSTRACT

Bioavailability File: METRONIDAZOLE
Evren H. TURGUT*, Mine ÖZYAZICI*^,o
*Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100 Bornova, İzmir, TURKEY.
^oCorresponding Author

Summary
Metronidazole is an antimicrobial nitroimidazole derivative, which was originally introduced to treat Trichomonas vaginalis but nowadays is used for the treatment of anaerobic and protozoal infections. Metronidazole is bactericidal through toxic metabolites, which cause deoxyribonucleic acid (DNA) strand breakage. It has a bioavailability of more than 90% after oral administration. The drug is metabolized by the liver and the hydroxy-metabolite has also a therapeutic effect. In this review, the physicochemical structure, assay methods, pharmacological and pharmacokinetical properties, and bioavailability of metronidazole are summarized.

Key Words :
Metronidazole, bioavailability, pharmacokinetics, pharmacology, drug interactions.