Synthesis and Pharmacology of Some New N,N-Disubstituted
Dithiocarbamate Derivatives
Fügen ÖZKANLI*, Ahu GÜNEY USANMAZ*, Keriman ÖZADALI*,°,
Engin YILDIRIM** and Kevser
EROL**
*
Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
Hacettepe University, Ankara, Turkey.
** Department of Pharmacology, Faculty of Medicine, Osman
Gazi University, Eskiţehir, Turkey.
° Corresponding Author E-mail: kozadali@hacettepe.edu.tr
Summary
In this study, twenty two new N,N-disubstituted
dithiocarbamate derivatives were synthesized. The structures
of the compounds were confirmed by IR, 1H-NMR, mass
spectroscopy and elemental analysis. Anticholinergic
activities of the compounds were evaluated by the tests
performed on isolated rat ileum and were compared with
atropine sulfate. 1-(Diphenylamino)-1-oxopropan-2-yl
4-methylpiperazine dithiocarbamate 18 and
1-(α-naphthylamino)-1-oxopropan-2-yl 4-methylpiperidine
dithiocarbamate 25 were found to show the best activity.
Key Words :
Dithiocarbamic acid esters, anticholinergic
activity.
