Formulation and
Evaluation of Chronomodulated Floating Drug Delivery System
of Famotidine
Piyush PATEL*,º,
Dinesh PURI**, Anil BHANDARI**, Deepak CHOUDHARY**, Rambabu
SHARMA**, Vivek BHATELE***
* School of Pharmacy, SRTM University, Nanded, Maharastra,
India
** Faculty of Pharmacetical Sciences, Jodhpur National
University, Jodhpur, Rajasthan, India
*** Intas Vivek Bhatele, Intas Pharma Ltd., Plot No. 5,6,7
Pharmez, Taluka-Sanand Dist. Ahmedabad, Gujrat, India
° Corresponding Author E-mail: puridinesh105@gmail.com
Summary
Chronomodulated floating drug delivery system for famotidine
was successfully prepared, evaluated and optimized for their
desired effect. By using present drug delivery system, one
can deliver famotidine locally to the stomach with certain
period of lag time. Different levels of percentage weight
ratio of ethyl cellulose to hydroxypropyl cellulose and
different coating levels were successfully optimized by
using statistical analysis. Combining 32 factorial design
and response surface methodology %weight ratio of polymers
and coating levels were optimized for desired lag time of
off release and cumulative drug release. Response surface
methodology represents combined effect of both independent
variables on dependent variables. So, we can predict optimum
levels of independent variables for desired responses. For
the present study of formulating chronomodulated floating
drug delivery system optimized coating level/%weight gain
was 7.50% and percentage weight ratio of ethyl cellulose to
hydroxypropyl methyl cellulose was 78.50% that can give
observed lag time of 218 minute and percentage cumulative
drug release 88.21% with minimum percentage error with
predicted values from the software.
Chronomodulated floating drug delivery of famotidine can
effectively give night time relief from nocturnal acid
breakthrough (pH<4 at 2-4 am) in patients with peptic ulcer,
duodenum ulcer and Gastro esophageal reflux disease.
Key Words :
Chronomodulated floating drug delivery
system, Famotidine, Nocturnal gastric acid.
