OXIMES AND OXIME ETHERS: I. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES

Arzu KARAKURT*, Sevim DALKARA*°

*Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Sihhiye, Ankara, TURKEY.
°Corresponding Author

Summary:
Oximes are derived from the reactions of aldehydes or ketones and hydroxlamine hydrochloride and show geometric (E/Z) isomerism due to the carbon-nitrogen double bond in their structure Oximes and their O-alkylethers are found in the structure of many drugs. These groups are frequently used for molecular modification to develop new drugs and for synthesis of many functional groups as starting compounds. Pharmacological and stereochemical properties and synthetic methods of oximes and oxime ethers have been reviewed in this article.

Key word:
Oxime, Oxime ether, Synthesis, Pharmacological properties and E/Z isomerism.