PREPARATION
AND DIFFUSIONAL EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES
CONTAININGIBUPROFEN MICROSPHERES
Tamer GÜNERÝ*o, Mesut ARICI*, Gökhan ERTAN*
*Ege University, Faculty of Pharmacy,
Department of Pharmaceutical Thechnology, 35100 SBornova,
Ýzmir - TURKEY.
oCorresponding Author
Summary
Sustained-release suppositories containing ibuprofen microspheres
were prepared with hydrophilic polyethylene
glycol (PEG) or lipophilic Witepsol bases. Microspheres
were prepared by solvent evaporation method. The effect
of stirring rate on the particle size and drug content
of the microspheres was investigated. Decrease in particle
size and drug content of microspheres was observed with
an increase in stirring rate. In-vitro dissolution studies
were performed in phosphate buffer solution (pH 7.2) at
100 rpm. All formulations exhibited non-Fickian diffusion
and first-order or Hixson-Crowell kinetics.
Differential scanning calorimetric analyses showed that
there were no crystal forms or decomposition products
of drug in the suppositories.
This study suggested that the sustained-release ibuprofen
suppositories could be prepared using PEG 400:PEG 4000
(5:95) combination with microspheres. These suppositories
can be more useful for clinical use.
Key Words :
Ibuprofen, microspheres, sustained-release
suppository.
