SYNTHESIS AND EVALUATION OF THE ANTICONVULSANT ACTIVITIES OF SOME 5-(4-SUBSTITUTEDBENZYLIDENE)-6-METHYL-4,5-DIHYDROPYRIDAZINE-3(2H)-ONES
Oya ÜNSAL*, *Ayla BALKAN^o*, Cenk AYPAK**, Berna TERZİOĞLU**, M. Zafer GÖKER**
* Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Sıhhiye, Ankara-TURKEY.
** Marmara University, School of Medicine, Department of Pharmacology and Clinical Pharmacology, 81326, Haydarpaþa, Ýstanbul - TURKEY.
^oCorresponding Author

Summary
In this study, starting from 3-benzylidene-4-oxopentanoic acid derivatives (1a-e), having 5-benzylidene-6-methyl-4,5-dihydropyridazine-3(2H)-one (2a-e) structure and their ester (3a-e), hydrazide (4a-e) and acetic acid (5a-e) derivatives were synthesized. The physical properties and UV absorptions of the five starting compounds (1a-e) and twenty target compounds (2a-5e) were determined. Their chemical structures were achieved by IR and 1 H-NMR spectral data. Additionally, elemental analysis data of the new compounds (1b, 2b, 3b, 4b, 5b, 3c, 4c, 5c, 2e, 3e, 4e and 5e) were done to identify the structures.
Anticonvulsant activities of the target compounds (2a-5e) were screened by pentylenetetrazole seizure model. It was observed that compound 2a showed an anticonvulsant effect similar to ethosuximide concerning the seizure grade

Key Words :
4,5-dihydropyridazine-3(2H)-one, 6-oxo-5,6-dihydropyridazinylacetate, 6-oxo-5,6-dihyd-ropyridazinylacetohydrazide, 6-oxo-5,6-dihyd-ropyridazinylacetic acid, anticonvulsant activity