CONDUCTIMETRIC DETERMINATION OF THE ANTIDEPRESSANTS AMITRIPTYLINE AND DOTHIEPIN HYDROCHLORIDES AND TRANYLCYPROMINE HEMISULPHATE IN THEIR PHARMACEUTICAL FORMULATIONS
Nour T. ABDEL GHANI*, Rasha M. EL-NASHAR*^o, Abeer A. BIOUMY*
* Cairo University, Chemistry Department, Faculty of Science, Giza,EGYPT.
^oCorresponding Author

Summary
Simple and sensitive conductimetric methods for the determination of amitriptyline hydrochloride, dothiepin hydrochloride and tranylcypromine hemisulphate are presented based on their ion associates with phosphotungstic and phosphomolybdic acids.
The effects of solvent, molar ratio, reagent concentration and temperature were studied, and the solubility products of the formed ion associates were calculated. The method was applied to the determination of the drugs in pure state and their pharmaceutical preparations with mean recovery values of 96.25-104.90, 95.75-103.12 and 97.90-102.30%, and coefficients of variation of 0.23-1.62, 0.22-0.63 and 0.25-1.35 for amitriptyline, dothiepin hydrochlorides and tranylcypromine hemisulphate, respectively. The mean recovery values were 97.28-101.77, 97.60-104.50, 102.30-104.50 and 99.2-103.40 with coefficients of variation of 0.20-1.05, 0.24-0.91, 0.26-0.65 and 0.43-1.19 for tryptizol tablets, prothiaden tablets, prothiaden capsule and parnetil tablets, respectively. This is nearly the same as in the case of determining pure drug samples, indicating the high selectivity of the method towards the studied drugs.

Key Words :
Antidepressants, amitriptyline HCl, dothiepin HCl, tranylcypromine hemi-sulphate, conductimetry.