CONTENT   

Research Articles

A Quality-by-Design Enabled Green and White Analytical UPLC Method for the Comprehensive Quantification of Nitroso Impurities in Tegoprazan Bulk Drug and Formulations

Krishna Vamsi KANDIMALLA*°, Ajay MANUKONDA**, Sambasiva Rao TUMMALA***,
Tangeti Venkata SWAMY****, Govindarao YEDLAPALLI*****

* ORCID: 0009-0004-4526-6045, Northeastern University, 360 Huntington Ave, Boston, Massachusetts – 02115, United States
** ORCID: 0009-0000-9896-4796, Northeastern University, 360 Huntington Ave, Boston, Massachusetts – 02115, United States
*** ORCID: 0000-0001-6686-7318, Stira Pharma Private Limited, Regulatory Affairs, Manjeera Trinity Corporate, Hyderabad – 500072, Telangana, India
**** ORCID: 0000-0001-8969-6806, Tagore Government Arts and Science College (Affiliated to Pondicherry University), Puducherry – 605008, Andhra Pradesh, India
***** ORCID: 0000-0003-2088-6438, Malineni Perumallu Pharmacy College, Pulladigunta, Guntur – 522017, Andhra Pradesh, India

Pages 1191-1212, Abstact, PDF (3,843 KB)

Evaluation of Antioxidant Properties and Metabolic Enzyme Inhibitory Potential of Medicago sativa L.

Sultan PEKACAR*, Ömer Furkan GÜVERTİ**°, Burçin ÖZÜPEK***, Didem DELİORMAN ORHAN****

* ORCID: 0000-0002-7782-9832, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye
** ORCID: 0009-0006-8258-7264, Department of Pharmacognosy, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye; Department of Pharmacognosy,
Faculty of Pharmacy, Gazi University, Ankara, Türkiye
*** ORCID: 0000-0003-2159-9860, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye
**** ORCID: 0000-0003-3916-4048, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye

Pages 1213-1226, Abstact, PDF (271 KB)

Multi-Scale In Silico Discovery of Potent SARS-CoV-2 RdRp Inhibitors

Sena ÇİNKILIÇ*, Erol AKGÜN**, Sevil ŞENKARDEŞ***, Necla KULABAŞ****°

* ORCID: 0009-0008-2453-9672, Institute of Health Sciences, Marmara University, Istanbul, Türkiye
** ORCID: 0000-0001-7391-6157, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye
*** ORCID: 0000-0002-0523-459X, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye
**** ORCID: 0000-0003-2273-5094, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye

Pages 1227-1248, Abstact, PDF (2,058 KB)

LC–MS-Based Untargeted Metabolomics Characterizes Caffeine-Associated Metabolic Remodeling in LPSStimulated RAW 264.7 Macrophages

Ozan KAPLAN*°, Ahmet AVCI**, Vahap Murat KUTLUAY***

* ORCID: 0000-0001-7429-9349, Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Ankara, Türkiye
** ORCID: 0000-0001-6311-5399, Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Ankara, Türkiye
*** ORCID: 0000-0003-4135-3497, Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Türkiye

Pages 1249-1268, Abstact, PDF (1,320 KB)

Development and In Vitro Assessment of Butyrylcholinesterase-Loaded Micelles for Protection Against Central Neurotoxicity Induced by Organophosphate Exposure

Gizem Ruya TOPAL*, Ozgur ESIM**°

* ORCID: 0000-0002-7715-6383, Department of Pharmaceutical Biotechnology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Türkiye
** ORCID: 0000-0002-6402-156X, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Türkiye

Pages 1269-1284, Abstact, PDF (574 KB)

Optimization of pH-Triggered Endosomal Escape in Lipid Nanoparticles Using 3ß[L-Histidinamide-Carbamoyl] Cholesterol for Therapeutic Aptamer Delivery

Ozan KILIÇKAYA*°, Cenk YILDIZ**

* ORCID: 0000-0003-2710-2149, Afyonkarahisar Health Sciences University, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology
** ORCID: 0000-0003-2672-8684, Afyonkarahisar Health Sciences University, Faculty of Pharmacy, Department of Pharmaceutical Technology

Pages 1285-12981, Abstact, PDF (1,163 KB)

Green Tea-Mediated Synthesis of Cadmium Oxide Nanoparticles: Characterization and Enhanced Antibacterial Activity Against Gram-Negative Pathogens

Alaa Z. SKHEEL*, Edmond CHEBLE**, Talib Z.T. AL MOSAWI***, Nadhim A.K. ABDLUL-HUSSEIN****, Hasaneen Kudhair ABDULL ABASS*****, Bushra J. MOHAMMED******, Ali JABER******°

* ORCID:0009-0006-1609-9748, Department of Medical Physics Sciences, College of Science, University of Kut, Wasit, 52001, Iraq
** ORCID: 0000-0001-9911-9025, Department of Medical Physics Sciences, College of Science, University of Kut, Wasit, 52001, Iraq
*** ORCID: 0000-0003-4358-7385, Department of Medical Physics Sciences, College of Science, University of Kut, Wasit, 52001, Iraq
**** ORCID: 0009-0009-1735-4714, Department of Medical Physics Sciences, College of Science, University of Kut, Wasit, 52001, Iraq
***** ORCID: 0000-0003-1185-0038, Department of Anesthesia Techniques, College of Health and Medical Techniques, University of Kut, Wasit, 52001, Iraq
****** ORCID: 0009-0002-1992-0000, Department of Medical Physics Sciences, College of Science, University of Kut, Wasit, 52001, Iraq
******* ORCID: 0000-0002-9180-8384, Faculty of pharmacy, Laboratoire de Recherche et Développement des Médicaments et des Produits Naturels RDMPN, Lebanese University, Beirut, Lebanon

Pages 1299-1314, Abstact, PDF (1,889 KB)

An Immunoinformatics-Based Multi-Epitope Vaccine Targeting Multiple Stages of Tuberculosis Pathogenesis

Sema KARABUDAK*°, Sümeyye ALTUNOK**, Emre Can BULUZ***

* ORCID: 0000-0002-3646-0442, Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Genetics, Ankara, Türkiye; Ankara Yıldırım
Beyazıt University Central Research Laboratory Application and Research Center, Ankara, Türkiye
** ORCID: 0000-0002-9004-0617, The Ohio State University Wexner Medical Center, Department of Neurology Columbus, 43210, OH, United States
*** ORCID: 0000-0002-2491-4347, Ege University, Department of Physics, Institute of Science and Technology, 35100, Bornova, İzmir, Türkiye

Pages 1315-1340, Abstact, PDF (2,590 KB)

Potassium Channels as Resilient Targets for Airway Smooth Muscle Relaxation Under Inflammatory Stress

Yesim KAYA-YASAR*°, Turgut Emrah BOZKURT**, Inci SAHIN-ERDEMLI***

* ORCID: 0000-0002-9938-3288, Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Türkiye
** ORCID: 0000-0001-8650-176X, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye
*** ORCID: 0000-0002-6403-0140, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye

Pages 1341-1352, Abstact, PDF (326 KB)

Comparative Genomics and Pangenome Analysis of L. Paracasei ATA-LTC-Lp121000 Strain: A Potential Probiotic from Türkiye

Halil KURT*°

* ORCID: 0000-0002-7392-527X, Medical Biology Department, Hamidiye International School of Medicine, University of Health Sciences, Istanbul 34668,
Türkiye

Pages 1353-1372, Abstact, PDF (4,562 KB)

Development and Characterization of an Amaranth Oil Nanoemulgel Incorporating Nisin and Hydrolyzed Wheat Protein for Topical Delivery in Atopic Dermatitis

Ebru ALTUNTAŞ*°, Ceren KOCA**, Müzeyyen AYDIN***

* ORCID: 0000-0003-2902-5554, İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Türkiye
** ORCID: 0000-0002-9972-0176, İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Türkiye; İstanbul University, Graduate School of Health Sciences, Istanbul, Türkiye
*** ORCID: 0000-0002-8082-9470, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, İstanbul University, Istanbul, Türkiye; İstanbul University, Graduate School of Health Sciences, Istanbul, Türkiye

Pages 1373-1390, Abstact, PDF (594 KB)

Biological Activities of the Endemic Plant Colchicum figlalii: Cytotoxic, Antioxidant, and Antimicrobial Properties

Tuğçe KELHASANOĞLU*, Anara BABAYEVA**, Esra DİBEK***, Kenan AKBAŞ****,
Çisem YILMAZ*****, Bekir ÇÖL******°

* ORCID: 0009-0009-3044-1273, Graduate School of Natural and Applied Sciences, Biology Department, Muğla Sıtkı Koçman University, Muğla, Türkiye
** ORCID: 0000-0001-6797-3366, Graduate School of Natural and Applied Sciences, Biology Department, Muğla Sıtkı Koçman University, Muğla, Türkiye
*** ORCID: 0000-0002-8110-5466, Köyceğiz Vocational School of Health Services, Pharmacy Services Program, Muğla Sıtkı Koçman University, Köyceğiz, Muğla, Türkiye
**** ORCID: 0000-0002-0198-4668, Köyceğiz Vocational School, Department of and Animal Production, Medicinal and Aromatic Plants Program, Köyceğiz, Muğla, Türkiye
***** ORCID:0009-0004-1380-8161, Graduate School of Natural and Applied Sciences, Biology Department, Muğla Sıtkı Koçman University, Muğla, Türkiye
****** ORCID: 0000-0001-8997-4116, Biotechnology Research Center, Muğla Sıtkı Koçman University, ALM Research Building, Muğla, Türkiye; Faculty of Science, Biology Department,
Muğla Sıtkı Koçman University, Muğla, Türkiye

Pages 1391-1406, Abstact, PDF (1,152 KB)

Experimental Screening and Kinetic Characterization of Natural SARS-CoV-2 3CLpro Inhibitors with Cell-Based Antiviral Evaluation

Beyza Tutku BICAKCI*, Oguz BAYRAKTAR**, Irem Evfa KUCUK***,
Aylin SENDEMIR****, Aykut OZKUL*****, Dilek YALCIN******°

* ORCID: 0000-0002-6638-0355, Department of Bioengineering, Ege University, Bornova, Izmir, 35100, Türkiye
** ORCID: 0000-0003-4210-2825, Department of Bioengineering, Ege University, Bornova, Izmir, 35100, Türkiye
*** ORCID: 0009-0005-2168-0951, Department of Bioengineering, Ege University, Bornova, Izmir, 35100, Türkiye
**** ORCID: 0000-0003-1818-6651, Department of Bioengineering, Ege University, Bornova, Izmir, 35100, Türkiye
***** ORCID: 0000-0001-5008-9443, Department of Virology, Faculty of Veterinary Medicine Ankara University, Ankara, 06070, Türkiye
****** ORCID: 0009-0002-5243-7434, Department of Bioengineering, Izmir Institute of Technology, Urla, Izmir, 35430, Türkiye

Pages 1407-1426, Abstact, PDF (2,272 KB)

Comparative Cytotoxicity and Wound Closure Effects of the Sunscreen UV Filters Bemotrizinol and Ethylhexyl Triazone in HaCaT and L929 Cell Lines

Duygu ALBAYRAK*, Mirkan ÖZIRMAK**, Hande YÜCE***, Dilan AŞKIN ÖZEK****,
Songül ÜNÜVAR*****°

* ORCID: 0009-0004-4425-0500, İnönü University, Faculty of Pharmacy, Malatya, Türkiye
** ORCID: 0009-0006-6963-1494, İnönü University, Faculty of Pharmacy, Malatya, Türkiye
*** ORCID: 0000-0003-2907-2019, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye
**** ORCID: 0000-0001-9075-4807, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Fırat University, Elazığ, Türkiye
***** ORCID: 0000-0001-8454-490X, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

Pages 1427-1436, Abstact, PDF (1,123 KB)

Evaluation of the Bioactivities of Commercially Available Cold-Pressed Borage Fixed Oil (Borago officinalis) and Geranium Essential Oil (Pelargonium graveolens)

Hülya YİĞİT*°, Aybüke Afra BABACAN**, Emine ÇELİKOĞLU***, Ceren BAŞKAN****

* ORCID: 0000-0002-9918-9258, Pharmacy services, Amasya University, Amasya, Türkiye
** ORCID: 0000-0003-4333-4732, Elderly care, Amasya University, Amasya, Türkiye
*** ORCID: 0000-0002-2064-9072, Amasya University, Suluova Vocational School, Department of Food Processing, Food Quality Control and Analysis Program,
Amasya, Türkiye
**** ORCID: 0000-0001-7849-4459, Department of Biology, Amasya University, Amasya, Türkiye

Pages 1437-1450, Abstact, PDF (345 KB)

Cardiometabolic Risks of Tramadol in the Setting of Obesity: Evidence from a High-Fat Diet Mouse Model

MD EBRAHIM*, MD. Abdur Rahman RIPON**, Kheirun Nahar JENI***, MD. Anisur RAHAMAN****, Imtiaz AHMAD*****, Mohammad Salim HOSSAIN******°

* ORCID: 0009-0008-2233-1093, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
** ORCID: 0000-0002-3139-567X, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
*** ORCID: 0009-0001-9927-9122, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
**** ORCID: 0009-0009-6006-4376, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
***** ORCID: 0000-0002-7611-5897, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
****** ORCID: 0000-0002-5710-1115, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh

Pages 1451-1464, Abstact, PDF (776 KB)

Decoding the Neoantigen Landscape: Designing Precision Vaccines for Cancer Immunotherapy

Sneha J. YADAV*, Nuha I. KHAMKAR**, Janhavi J. PATIL***, Diya H. AGA****, Pooja S. MANE*****, Dhanashree P. SANAP******°

* ORCID: 0009-0008-8793-0927, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
** ORCID: 0009-0000-9764-3157, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
*** ORCID: 0009-0000-4840-6358, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
**** ORCID: 0009-0001-3358-2735, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
***** ORCID: 0009-0003-6468-4050, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
****** ORCID: 0000-0002-4794-7598, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India

Pages 1465-1492, Abstact, PDF (591 KB)

Exploring NMDA Receptor Antagonists: Comprehensive Structural Analysis, Emerging Research Trends, and Therapeutic Prospects for Alzheimer’s Disease

Meenakshi MEHRA*°, Chandra Shekhar TAILOR**, Ramandeep SINGH***

* ORCID: 0000-0002-9973-6506, SGRR University, School of Pharmaceutical Sciences, Dehradun, India
** ORCID: 0009-0000-0073-3434, SGRR University, School of Pharmaceutical Sciences, Dehradun, India
*** ORCID: 0000-0002-7101-6304, Himachal Institute of Pharmacy, Himachal Pradesh, India

Pages 1493-1512, Abstact, PDF (896 KB)

A Current Alternative to Conventional Cancer Treatment Strategies: Photothermal Therapy

Armineh DELJAVAN GHODRATI* , Gulin AMASYA**°,
Ceyda Tuba SENGEL-TURK***°

* ORCID: 0009-0007-9814-2232, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye; Ankara University,
Graduate School of Health Sciences, Ankara, Türkiye
** ORCID: 0000-0002-0491-450X, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye
*** ORCID: 0000-0003-4123-7226, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye

Pages 1513-1536, Abstact, PDF (504 KB)

Natural Polymer-Based Microspheres for Anti-Inflammatory Drug Delivery: Materials, Characterization, and Therapeutic Applications

Ike WIDYANINGRUM*, Andang MIATMOKO**, Dewi Melani HARIYADI***°

* ORCID: 0000-0002-8873-4046, Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; Department of Pharmaceutical Sciences, Faculty of
Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia
** ORCID: 0000-0003-1658-0778, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; Pharmaceutics and Delivery Systems for Drugs, Cosmetics
and Nanomedicine (Pharm-DCN) Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; Inter-University Center of Excellent (IUCoE) of Health Autonomy-Drug Discovery,
Universitas Airlangga, Surabaya 60115, Indonesia
*** ORCID: 0000-0001-9357-3913, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; Pharmaceutics and Delivery Systems for Drugs, Cosmetics
and Nanomedicine (Pharm-DCN) Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia; Inter-University Center of Excellent (IUCoE) of Health Autonomy-Drug
Discovery, Universitas Airlangga, Surabaya 60115, Indonesia; Center of Excellent (PUIPT) Skin and Cosmetic Technology, Universitas Airlangga, Surabaya 60115, Indonesia

Pages 1537-1560, Abstact, PDF (687 KB)

The Endocannabinoid System in Allergic Airway Diseases: Mechanisms and Therapeutic Potential

Gaye ÖZTÜRK*, Tülay Özge ALPASLAN**, Kerem ERDOĞAN***,
Turgut Emrah BOZKURT****°

* ORCID: 0000-0002-2073-7865, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye
** ORCID: 0009-0002-7056-9107, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye
*** ORCID: 0009-0001-1924-9434, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye
**** ORCID: 0000-0001-8650-176X, Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye

Pages 1561-1578, Abstact, PDF (287 KB)

Overcoming Therapeutic Barriers in Alzheimer’s Disease: From Nanotechnology to Microneedles

Stela MUÇAJ*, Alperen AĞCA**, Tuğba GÜLSÜN***, R. Neslihan GÜRSOY****°

* ORCID: 0000-0001-6769-5781, Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Türkiye
** ORCID: 0009-0009-8568-650X, Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Türkiye
*** ORCID: 0000-0001-9359-276X, Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Türkiye
**** ORCID: 0000-0002-8589-2321, Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Türkiye

Pages 1579-1594, Abstact, PDF (810 KB)