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Araştırma Makaleleri

Investigation of Benzothiazole-Schiff Bases for Antimicrobial Activities Through ADMET, Molecular Docking, and DFT Analysis

Augustine Onuche SULE*, Olatunde ABIMBOLA MODUPE**, Banjo SEMIRE***°

* ORCID: 0009-0006-3953-209X, Department of Chemistry, Federal University, Lokoja, Nigeria
** ORCID: 0000-0002-6253-8645, Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria
*** ORCID: 0000-0002-4173-9165, Computational Chemistry Research Laboratory, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

Pages 1-22, Özet, PDF (3,898 KB)

Development and Validation of RP-HPLC for Determination Bedaquiline Fumarate in Nanostructured Lipid Carriers, Tablets, and Human Plasma Using Design of Experiment Method

Asti RAHAYU*, SATRIALDI**, Neng Fisheri KURNIATI***,
Rachmat MAULUDIN****°

* ORCID: 0009-0004-4731-942X, Doctoral Program in Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia; Department of Pharmaceutics,
Faculty of Health Sciences, Universitas PGRI Adi Buana Surabaya, Indonesia
** ORCID: 0000-0001-9973-4044, Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
*** ORCID: 0000-0001-9973-4044, Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
**** ORCID: 0000-0002-3729-0254, Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia

Pages 23-40, Özet, PDF ( 591 KB)

Unveiling The Therapeutic Potential of Nyctanthes arbor-tristis Linn. In Breast Cancer: A Network Pharmacology and Molecular Docking Approach

Omkar TIPUGADE*, Jyotiram SAWALE**°, Namdeo JADHAV***

* ORCID: 0000-0002-3723-9133, Research Scholar, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India, 415539
**ORCID: 0000-0002-8383-7249, Department of Pharmacognosy, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India, 415539
***ORCID: 0000-0001-5230-6659, Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India, 415539

Pages 41-52, Özet, PDF ( 138 KB)

Intranasal Delivery of Nicotine Via Thermoresponsive Hydrogel Systems: Design, Characterization, and In Vitro Evaluation

Sema ARISOY*°, Özlem YAPAR**, Betül KARAKURT***, Ramazan BAKAL****,
Dilara ÖRGÜL*****

* ORCID: 0000-0003-2798-1884, Department of Pharmaceutical Technology, Faculty of Pharmacy, Selcuk University, Konya, Turkey
** ORCID: 0009-0003-4602-3339, Faculty of Pharmacy, Selcuk University, Konya, Turkey
*** ORCID: 0009-0007-4137-2387, Faculty of Pharmacy, Selcuk University, Konya, Turkey
**** ORCID: 0009-0000-0112-7087, ILKO Pharmaceuticals, 42280, Konya, Turkey
***** ORCID: 0000-0002-8947-4995, Department of Pharmaceutical Technology, Faculty of Pharmacy, Selcuk University, Konya, Turkey

Pages 53-66, Özet, PDF ( 905 KB)

Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Ipomoea Hederifolia Linn

Kailas Krishnat MALI*°, Nitin Hindurao SALUNKHE**, Suraj Ashok SUTAR***,
Remeth Jacky DIAS****, Balaji Dattatray JADHAV*****

* ORCID: 0000-0002-1789-3592, Adarsh College of Pharmacy, Vita, A/p – 421/2, Near MIDC, Khambale (Bha.), Vita, Tal- Khanapur 415311 Dist- Sangli, Maharashtra, India
**ORCID: 0009-0002-1526-4423, Adarsh College of Pharmacy, Vita, A/p – 421/2, Near MIDC, Khambale (Bha.), Vita, Tal- Khanapur 415311 Dist- Sangli, Maharashtra, India
***ORCID: 0009-0009-8795-2672, Adarsh College of Pharmacy, Vita, A/p – 421/2, Near MIDC, Khambale (Bha.), Vita, Tal- Khanapur 415311 Dist- Sangli, Maharashtra, India
****ORCID: 0000-0002-8234-9630, Department of Pharmacy, Government College of Pharmacy, Karad 415124 Dist- Satara, Maharashtra, India
*****ORCID: 0009-0003-8727-0854, Adarsh College of Pharmacy, Vita, A/p – 421/2, Near MIDC, Khambale (Bha.), Vita, Tal- Khanapur 415311 Dist- Sangli, Maharashtra, India

Pages 67-88, Özet, PDF ( 1,263 KB)

Evaluation for Dissolution Profile Similarity of Multisource Generic Products Containing Favipiravir in the Treatment of COVID-19: Model-independent Bootstrap f₂ and Model-dependent Approaches

Duygu YILMAZ USTA*°

* ORCID: 0000-0003-4035-7656, Gazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye

Pages 89-104, Özet, PDF ( 446 KB)

Rethinking Oral Infection Control: Antimicrobial Peptides and Essential Oils as Alternative Antibacterial Agents

Murat Sefa KARAASLAN*, Nurten ALTANLAR**°, Sinem ASLAN ERDEM***

* ORCID: 0009-0001-8215-2491, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ankara University, Ankara, Türkiye; Graduate School of
Health Sciences, Ankara University, Ankara, Türkiye
** ORCID: 0000-0003-2977-2269, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ankara University, Ankara, Türkiye
*** ORCID: 0000-0003-1504-1916, Department of Pharmacocnosy, Faculty of Pharmacy, Ankara University, Ankara, Türkiye

Pages 105-114, Özet, PDF ( 162 KB)

Investigation of Synthesis, X-Ray Characterization and Biological Activities of Copper(II) Imidazole Complexes

Sevda ER*°, Hakan ÜNVER**, Banu BARUTCA***

* ORCID: 0000-0002-8210-0915, Department of Pharmacy, Yunus Emre Vocational School, Anadolu University, 26470, Eskişehir, Turkey
** ORCID: 0000-0002-4858-4039, Department of Chemistry, Faculty of Science, Eskisehir Technical University, 26470, Eskişehir, Turkey
*** ORCID: 0000-0003-3533-170X, Yunus Emre Vocational School, Anadolu University, 26470, Eskişehir, Turkey

Pages 115-128, Özet, PDF ( 692 KB)

Mucoadhesive Delivery of Alfuzosin HCl Using Hupu Gum: Insights from In Silico Docking and Ex Vivo – In Vivo Adhesion Studies

Rajeswari ALETI*°, Monika NIJHAWAN**, Pavan KUMAR THOTA***,
Bhavana JIDIGE****

* ORCID: 0009-0001-8894-9063, Department of Pharmaceutics, Gland Institute of Pharmaceutical Sciences, Medak District, Telangana, India
** ORCID: 0000-0002-3564-0257, Department of Pharmaceutics, Professor, GokarajuRangaraju College of Pharmacy, Osmania University, Hyderabad, Telangana, India.
*** ORCID: 0009-0009-5890-3636, Department of Pharmaceutics, GokarajuRangaraju College of Pharmacy, Osmania University, Hyderabad, Telangana, India.
**** ORCID: 0009-0007-0819-1357, Department of Pharmaceutics, GokarajuRangaraju College of Pharmacy, Osmania University, Hyderabad, Telangana, India.

Pages 129-146, Özet, PDF ( 1,726 KB)

Investigation of Maillard-Type Drug–Excipient Interaction Between Rivaroxaban and Lactose: Implications for Stability and In Vitro Anticoagulant Activity

Kunal BACHCHHAO*°, Ajaygiri GOSWAMI**, Chandragauda PATIL***, Dipak PATIL****

* ORCID: 0000-0003-1095-1961, University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon, Maharashtra, India.
** ORCID: 0000-0002-4472-863X, University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon, Maharashtra, India.
*** ORCID: 0000-0001-8401-1978, Department of Pharmacology, R.C. Patel Institute of Pharmaceutical Education & Research Shirpur, Dist Dhule MS.425405
**** ORCID: 0000-0002-4826-4537, Department of Quality Assurance K. K. Wagh College of Pharmacy, Nasik MS 422003

Pages 147-162, Özet, PDF ( 1,349 KB)

Anticancer Potential of Piperidine-Substituted Mannich Bases: Evidence of Cytotoxic Activity and Apoptotic Effects on Various Cancer Cells

Gülşah KARAKAYA*, Canan SEVİMLİ GÜR**, Mutlu AYTEMİR***°

* ORCID: 0000-0002-3827-7537, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, İzmir Katip Çelebi University, İzmir, Türkiye
** ORC ID: 0000-0002-2210-5925, Department of Basical Sciences, Faculty of Pharmacy, İzmir Katip Çelebi University, İzmir, Türkiye
*** ORCID: 0000-0002-1433-0356, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye

Pages 163-174, Özet, PDF (226 KB)

Dornase Alfa as a Potential Treatment Option for SARSCoV-2: In Vitro Insights

Derya DİLEK KANÇAĞI*°, Cihan TAŞTAN **, Kevser Buse KARADENİZ***,
Selen ABANUZ****, Didem ÇAKIRSOY*****, Yaren BÜYÜKÇOLAK******,
Sezer AKYÖNEY*******, Gözde SIR KARAKUŞ********, Bulut YURTSEVER*********,
Koray YALÇIN**********, İsmail Tuncer DEĞİM***********, Ercüment OVALI************

* ORCID: 0000-0003-4725-3200, Department of Biochemistry, Faculty of Pharmacy, Fenerbahçe University, Istanbul, Turkey; Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
** ORCID: 0000-0002-4173-6634, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey; Transgenic Cell Technologies and Epigenetic Application and Research Center (TRGENMER), Üsküdar University, Istanbul, Turkey;
Molecular Biology and Genetics Department, Faculty of Engineering and Natural Science, Üsküdar University, Istanbul, Turkey
*** ORCID: 0000-0001-5370-6865, Institute of Health and Science, Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
**** ORCID: 0000-0002-6136-5033, Institute of Health and Science, Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
***** ORCID: 0000-0002-1293-9520, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey; Institute of Health and Science, Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
****** ORCID: 0000-0002-5988-5312, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey; Institute of Health and Science, Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
******* ORCID: 0000-0003-2514-4142, Institute of Health and Science, Department of Biostatistics and Bioinformatics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
******** ORCID: 0000-0002-0682-5869, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
********* ORCID: 0000-0002-9269-8383, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey; Institute of Health and Science, Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
********** ORCID: 0000-0003-3454-9870, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey; Institute of Health and Science, Department of Medical Biotechnology, Acibadem Mehmet Ali Aydinlar University, Istanbul,
Turkey; Acıbadem Altunizade Hospital, Department of Pediatric Hematology and Oncology, Istanbul, Turkey
*********** ORCID: 0000-0002-9329-4698, Pharmaceutical Technology Department, Faculty of Pharmacy, Biruni University, Istanbul, Turkey
************ ORCID: 0000-0002-4782-5355, Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey

Pages 175-188, Özet, PDF ( 1,642 KB) Suplement PDF(1,233 KB)

Smoking Behavior, Nicotine Dependence, and Awareness of Cessation Methods Among Pharmacy Students: A Cross-Sectional Analysis

Nesligül ÖZDEMİR AYDURAN*°, Nida AÇAR**, Zeynep Ülkü GÜN***

* ORCID: 0000-0003-2551-9549, Department of Clinical Pharmacy, Faculty of Pharmacy, Gazi University, Ankara, Türkiye
** Faculty of Pharmacy, Inonu University, Malatya, Türkiye
*** ORCID: 0000-0002-7131-6585, Department of Clinical Pharmacy, Faculty of Pharmacy, Trakya University, Edirne, Türkiye

Pages 189-206, Özet, PDF ( 185 KB)

A Cross-Sectional Survey on the Attitudes of Future Pharmacists Towards Phytotherapeutic Product Use and Safety

Suheda Rumeysa OSMANLIOGLU DAG*°, Ceyhan CERAN SERDAR**,
Seyma YIGITBASI***, Iffet Irem TATLI CANKAYA****

* ORCID: 0000-0002-0243-3454, Department of Pharmaceutical Botany, Faculty of Pharmacy, Inonu University, Malatya, Turkiye
** ORCID: 0000-0002-2921-7030, Department of Medical Biology and Genetics, School of Medicine, Ankara Medipol University, Ankara, Turkiye
*** ORCID: 0009-0006-0962-7362, Faculty of Pharmacy, Inonu University, Malatya, Turkiye
**** ORCID: 0000-0001-8531-9130, Department of Pharmaceutical Botany, Faculty of Pharmacy, Hacettepe University, Ankara, Turkiye

Pages 207-222, Özet, PDF ( 400 KB)

The Effects of Garlic (Allium sativum L.) and Allicin on Heart Rate: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies

Rita RAKHMAWATI*°, Rasmaya NIRURI**

* ORCID: 0000-0001-8905-5531, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Surakarta, Indonesia
** ORCID: 0000-0002-9684-2573, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Surakarta, Indonesia

Pages 223-238, Özet, PDF ( 350 KB)

An Integrated Taguchi Design and Response Surface Methodological Approach for Development of Bedaquiline-Loaded Nanostructured Lipid Carriers

Rachmat MAULUDIN*°, Asti RAHAYU**, SATRIALDI***, Neng Fisheri KURNIATI****

* ORCID: 0000-0002-3729-0254, Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
** ORCID: 0009-0004-4731-942X, Program Doctoral, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia; Department of Pharmaceutics,
Faculty of Health Sciences, Universitas PGRI Adi Buana Surabaya, Indonesia
*** ORCID: 0000-0001-9973-4044, Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
**** ORCID: 0000-0001-9973-4044, Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia

Pages 239-256, Özet, PDF (1,422 KB)

Anti-Aging Activity of Ethanol Extract of the Oil Palm Mesocarp (Elaeis guineensis Jacq.): In Vitro and In Silico Studies

Retno WIDYOWATI*°, Anisa Yustikka PUTRI**, SUKARDIMAN***,
Irawati SHOLIKHAH****, Rosita HANDAYANI*****, Katsuyoshi MATSUNAMI******,
Hsin-I CHANG*******

* ORCID: 0000-0002-6166-1289, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo, Surabaya 60115, East Java, Indonesia
** ORCID: 0009-0001-0549-4850, Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga. Jl. Dr. Ir. H. Soekarno, Surabaya 60115, East Java, Indonesia
*** ORCID: 0000-0001-9689-5088, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo, Surabaya 60115, East Java, Indonesia
**** ORCID: 0000-0002-0124-8302, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo, Surabaya 60115, East Java, Indonesia
***** ORCID: 0000-0002-3304-3328, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C, Mulyorejo, Surabaya 60115, East Java, Indonesia
****** ORCID: 0000-0002-8034-0253, Biomedical & Health Sciences, Hiroshima University, Japan 734-8853
******* ORCID: 0009-0009-7373-3882, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan

Pages 257-274, Özet, PDF ( 1,810 KB)

Total Phenolic and Flavonoid Contents of Ethanol Extract of Manilkara kauki Leaves and Antibiofilm Activity Test Against Biofilms of Pseudomonas aeruginosa

Lilik FARKHIYAH*, Tukiran TUKIRAN**°

* ORCID: 0009-0007-8205-9864, Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, Indonesia
** ORCID: 0000-0001-6613-128X, Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, Indonesia

Pages 275-290, Özet, PDF ( 771 KB)

Cimicifuga racemosa (L.) Nutt.: Pharmacological Effects, Using Areas and Current Clinical Data

Ecenur BAYIR*°, Gözde ELGİN CEBE**

* ORCID: 0000-0003-4480-4417, Department of Pharmaceutical Botany, Faculty of Pharmacy, Ege University İzmir, Türkiye
** ORCID: 0000-0002-7253-3864, Department of Pharmaceutical Botany Faculty of Pharmacy, Ege University İzmir, Türkiye

Pages 291-304, Özet, PDF ( 642 KB)

Therapeutic Applications of Garlic (Allium sativum L.) Essential Oil: A Review on Different Extraction Methods and Characterization on Its Bioactive Compound

Nastiti Nur INDRIYANI*°, Dwi Ayu Lutfiani AMALIA**, Maulana Nur ARDIAN***,
Didi RAMADANI****

* ORCID: 0000-0002-0567-5512, D3 Pharmaceuticals and Food Analysis, STIKes Ibnu Sina Ajibarang, Ajibarang, Indonesia
** ORCID: 0009-0005-2880-5286, Department of Biology, Jenderal Soedirman University, Purwokerto, Indonesia
*** ORCID: 0009-0006-4038-0441, Department of Food Science and Technology, G.B. Pant University of Agriculture and Technology, Pantnagar, India
**** ORCID: 0009-0009-0557-1295, Department of Biology, Jenderal Soedirman University, Purwokerto, Indonesia

Pages 305-326, Özet, PDF ( 323 KB)

Tailored Polymers in Therapeutics: Bridging Drug Delivery and Biomedical Engineering

Manjeet KAUR*, Lakhvir KAUR**°, Gurjeet SINGH***, Lovepreet SINGH****,
RK DHAWAN*****, Navdeep KAUR******, Manbir KAUR*******, Peeyush SHARMA********

* ORCID: 0000-0001-8977-398X, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, 143001
** ORCID: 0000-0001-8091-2365, School of Pharmaceutical Sciences, CT University, Ludhiana, Punjab, 142024
*** ORCID: 0000-0003-4399-4693, Department of Pharmaceutics, ASBASJSM College of Pharmacy, Ropar, Punjab, 140111
**** ORCID: 0000-0003-3217-9431, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, 143001
***** ORCID: 0000-0002-8587-6807, Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, 143001
****** ORCID: 0000-0002-6213-4640, Department of Chemistry, Khalsa College, Amritsar, Punjab, 143001
******* ORCID: 0009-0007-3851-6335, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, 143001
******** ORCID: 0000-0002-1025-830X, Department of Pharmachemistry, Khalsa College of Pharmacy, Amritsar, 143001

Pages 327-350, Özet, PDF ( 909 KB)

Medicinal Chemistry Approaches for Combatting SARS-CoV-2 and COVID-19 Therapeutics

Neelottama KUSHWAHA*°, Swatantra K.S. KUSHWAHA**, Anmol KUMAR***

* ORCID: 0000-0001-9653-1313, Krishna Institute of Pharmacy & Sciences, Kanpur-208017, India
** ORCID: 0000-0002-1004-6323, Krishna Institute of Pharmacy & Sciences, Kanpur-208017, India
*** ORCID: 0009-0009-1566-4874, Krishna Institute of Pharmacy & Sciences, Kanpur-208017, India

Pages 351-382, Özet, PDF ( 1,181 KB)

Repurposing Antidiabetic Agents as Potential Therapeutics in Neurodegenerative Diseases: Current Status and Future Perspectives

Ahmet Hüsamettin BARAN *°

* ORCID: 0000-0003-0830-313X, Republic of Türkiye Ministry of Health, Türkiye Medicines and Medical Devices Agency, Ankara, Türkiye

Pages 383-402, Özet, PDF (1,031 KB)

Asbestos Exposure in Occupational and Environmental Settings Following the 2023 Earthquake in Türkiye: A Focused Review

Hürü DİKEÇ*, Aysun ÖKÇESİZ HACISEYİTOĞLU**°

* ORCID: 0009-0002-4106-6025, Faculty of Pharmacy, Erciyes University, 38280, Kayseri, Türkiye
** ORCID: 0000-0001-9130-2853, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Erciyes University, 38280, Kayseri, Türkiye

Pages 403-418, Özet, PDF ( 583 KB)

The Role of Glucocorticoids in Hepatic Gluconeogenesis, Associated Pathologies, and Novel Therapeutic Approaches

Yusuf Anil AY*, Elif CADIRCI**°

* ORCID: 0009-0002-6007-694X, Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Türkiye
** ORCID: 0000-0003-0836-7205, Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Türkiye

Pages 419-434, Özet, PDF ( 343 KB)