2026 Cilt 51, Sayı 2

İÇİNDEKİLER  

Araştırma Makalesi

Qualitative and Quantitative In Silico Assessment of Acute Toxicity of PFOA and PFOS

Fuat KARAKUŞ*º

* ORCID: 0000-0002-5260-3650, Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Van Yuzuncu Yil University, 65080, Tuşba, Van, Türkiye

Sayfalar 435-452, Özet, PDF (934 KB)

Development and In Vitro Characterization of Neusilin® US2-Based Solid Self-Nanoemulsifying Drug Delivery System for Oral Administration of Finasteride

Duygu YILMAZ USTA*°, Fatma Nur ONCEL**, Gözde BEBEK***,
Sibel ILBASMIS-TAMER****

* ORCID: 0000-0003-4035-7656, Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye
** ORCID: 0009-0002-7356-7617, Gazi University, Faculty of Pharmacy, Ankara, Türkiye
*** ORCID: 0000-0001-9593-8373, Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye
**** ORCID: 0000-0003-0361-7105, Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye

Sayfalar 453-474, Özet, PDF (3,168 KB)

Fabrication and Evaluation of Lercanidipine Hydrochloride Solid Dispersion Tablets

Ayesha NAZ*°, Syeda KULSUM**, Salma BEGUM***, Donthula SRILATHA****

* ORCID: 0000-0001-9908-4512, Department of Pharmaceutics, MRM College of Pharmacy, Ibrahimpatnam, Telangana-501510, India
** ORCID: 0000-0002-7028-3830, Department of Pharmaceutical Analysis, MRM College of Pharmacy, Ibrahimpatnam, Telangana-501510, India
*** ORCID: 0009-0002-0367-2235, Department of Pharmaceutics, MRM College of Pharmacy, Ibrahimpatnam, Telangana-501510, India
**** ORCID: 0009-0001-4441-2467, Department of Pharmaceutics, Brilliant Grammar School Educational Society’s Group of Institutions- integrated Campus,
Abdullahpurmet, Hyderabad, Telangana, India- 501505.

Sayfalar 475-488, Özet, PDF (1,396 KB)

Development and Optimization of Andrographis paniculata Extract Nanoemulsion by Low-Energy Method Using Simplex Lattice Design

Metha Anung ANINDHITA*,**, Triana HERTIANI***, Khadijah ZAI****,
Akhmad Kharis NUGROHO*****°

* ORCID: 0009-0008-2610-8040, Doctoral Program in Pharmaceutical Science, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
** Department of Pharmaceutics, Faculty of Pharmacy, Universitas Pekalongan, Central Java, Indonesia
*** ORCID: 0000-0002-1756-2478, Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
****ORCID: 0000-0003-4447-6177, Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
***** ORCID: 0000-0003-4277-5413, Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia

Sayfalar 489-502, Özet, PDF (1,107 KB)

Synthesis and Biological Evaluation of Tacrine Derivatives as Potential Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer’s Disease

Gulsah BAYRAKTAR*, Sulunay PARLAR**°, Gunes COBAN***, Vildan ALPTUZUN****

* ORCID: 0000-0001-7271-1619, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey
** ORCID: 0000-0002-2892-5932, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey
*** ORCID: 0000-0003-4512-4392, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey
**** ORCID: 0000-0002-1477-4440, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35040, Izmir, Turkey

Sayfalar 503-516, Özet, PDF (572 KB)

Effects of Diminazene Aceturate on Isolated Rat Bladder Tissue: Role of Nitric Oxide and Cyclooxygenase Pathways

Yagmur OKCAY*°, Zeliha RUMANLI**, Emre AVCI***, Ismail Mert VURAL****

* ORCID: 0000-0003-1254-7612, Department of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences Ankara, Türkiye
** ORCID: 0000-0003-0550-6281, Department of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences Ankara, Türkiye
*** ORCID: 0000-0003-1046-8208, Department of Biochemistry, Gulhane Faculty of Pharmacy, University of Health Sciences Ankara, Türkiye
**** ORCID: 0000-0002-0011-9023, Department of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences Ankara, Türkiye

Sayfalar 517-530, Özet, PDF (939 KB)

Molecular Docking-Guided Coformer Selection and Cocrystallization for Enhanced Biopharmaceutical Performance of Tolvaptan

Monika NIJHAWAN*°, Dedipya Goda Srivalli VANGALA**, Rajeswari ALETI***,
Sailaja GUNNAM****, G. Kinnera Ratna SRI*****

* ORCID: 0000-0002-3564-0257, Department of Pharmaceutics, Associate Professor, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India
** ORCID: 0009-0005-1405-475X, Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India
*** ORCID: 0009-0001-8894-9063, Department of Pharmaceutics, Assistant Professor, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India
**** ORCID: 0009-0007-2550-4001, Department of Pharmaceutics, Associate Professor, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India
***** ORCID: 0000-0001-9763-9174, Department of Pharmacology, Assistant Professor, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India

Sayfalar 531-544, Özet, PDF (869 KB)

Real-World Patterns of Cyclobenzaprine–Dexketoprofen Co-prescribing in Türkiye: A Nationwide Pharmacy Network-Based Study

Bulent GUMUSEL*°, Belma KOCER GUMUSEL**

* ORCID: 0000-0002-7533-7949, Department of Pharmacology, Faculty of Pharmacy, Istanbul Okan University, İstanbul, Türkiye
** ORCID: 0000-0003-4311-2291, Department of Toxicology, Faculty of Pharmacy, Istanbul Okan University, İstanbul, Türkiye

Sayfalar 545-554, Özet, PDF (126 KB)

Development and In Vitro Assessment of Cumin Essential Oil Nanoemulsion and Nanoemulgel Formulations for Vaginal Candidiasis

Imren ESENTURK-GUZEL*°, Sayra POLAT**, Asli GÜRBÜZ YURTSEVER***, Luceyn
ABDO****, Meryem Sedef ERDAL*****, Cemre ÖZKANCA******, Sibel DÖŞLER*******

* ORCID: 0000-0002-4069-2035, Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, 34668, Istanbul, Türkiye
** ORCID: 0000-0002-4723-6294, Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, 34668, Istanbul, Türkiye
*** ORCID: 0000-0002-1389-1581, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116, Istanbul, Türkiye
**** ORCID: 0000-0001-5627-4041, Department of Pharmaceutical Technology, Hamidiye Institute of Health Sciences, University of Health Sciences, 34668, Istanbul, Türkiye
***** ORCID: 0000-0001-6220-2036, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116, Istanbul, Türkiye
****** ORCID: 0000-0002-0342-2060, Hamidiye Vocational School of Health Services, University of Health Sciences, 34668, Istanbul, Türkiye
******* ORCID: 0000-0001-5223-4755, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye

Sayfalar 555-572, Özet, PDF (609 KB)

Quantitative Analysis of Active Compounds in a Three-Component Pharmaceutical Formulation Using Multivariate Calibration Methods

Nazangül ÜNAL*, Asiye ÜÇER**, Erdal DİNÇ***°

* ORCID: 0000-0001-9481-1354, Department of Pharmacy Services, Eşme Vocational School, Uşak University, 64600, Uşak, Türkiye
** ORCID: 0000-0002-9286-3211, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara Yıldırım Beyazıt University, 06010 Etlik, Keçiören, Ankara, Türkiye
*** ORCID: 0000-0001-6326-1441, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06560 Yenimahalle, Ankara, Türkiye

Sayfalar 573-586, Özet, PDF (408 KB)

Integration of TLC-, FTIR-, and 1H-NMR-based metabolomics and chemometric analyses for discriminating the geographical origin of Orthosiphon aristatus (Blume) Miq.

Fitriana Hayyu ARIFAH *,**, Abdul ROHMAN***, Wawan SUJARWO****,
Agung Endro NUGROHO*****°

* ORCID: 0000-0002-4294-1146, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
** ORCID: 0000-0002-4294-1146, Research Group of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
*** ORCID: 0000-0002-1141-7093, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
**** ORCID: 0000-0001-8858-9769, Ethnobiology Research Group, Research Center for Biology, National Research and Innovation Agency (BRIN), Bogor, Indonesia
***** ORCID: 0000-0001-7840-8493, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia

Sayfalar 587-608, Özet, PDF (943 KB)

Assessment of Hospital Pharmacists’ Knowledge, Attitudes, and Practices Regarding Therapeutic Drug Monitoring in Adana, Türkiye: A Cross-Sectional Study

Emir EMLİK*, Sevgin MEMİLİ**°, Nursel SÜRMELİOĞLU***

* ORCID: 0009-0002-4948-3958, Department of Clinical Pharmacy, Faculty of Pharmacy, Çukurova University, Adana, Türkiye
** ORCID: 0009-0000-3480-2296, Department of Clinical Pharmacy, Faculty of Pharmacy, Çukurova University, Adana, Türkiye; Department of Clinical Pharmacy,
Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye
*** ORCID: 0000-0001-7758-7100, Department of Clinical Pharmacy, Faculty of Pharmacy, Çukurova University, Adana, Türkiye

Sayfalar 609-622, Özet, PDF (134 KB)

Development of Ornidazole-Loaded Emulgel: Formulation Optimization and In Vitro Characterization

Özlem KRAL*°, İrem ÖZEL**

* ORCID: 0000-0003-1420-8462, Ağrı İbrahim Çeçen University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ağrı, 04100, Türkiye
** ORCID: 0009-0007-6437-4860, Ağrı İbrahim Çeçen University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ağrı, 04100, Türkiye

Sayfalar 623-638, Özet, PDF (637 KB)

Combinatorial Antitumor Effect of Vinblastine and the PI3K-Akt-mTOR Pathway Inhibition in AML Cells

Havva Berre AYVAZ*, Emel Başak GENCER AKÇOK**°

* ORCID: 0000-0002-5873-7879, Abdullah Gul University, Graduate School of Engineering and Science, Bioengineering Department, Kayseri, Turkey
** ORCID: 0000-0002-6559-9144, Abdullah Gul University, Faculty of Life and Natural Sciences, Molecular Biology and Genetics Department, Kayseri, Turkey

Sayfalar 639-656, Özet, PDF (1,385 KB)

Development and Optimization of Fast-Dissolving Oral Films Containing Metformin HCl and Curcumin–β-Cyclodextrin Inclusion Complex Using a Box–Behnken Design

Emine Dilek ÖZYILMAZ*º

* ORCID: 0000-0002-1791-3055, Eastern Mediterranean University, Faculty of Pharmacy, Department of Pharmaceutical Technology, North Cyprus, Famagusta,
Mersin 10, Türkiye

Sayfalar 657-674, Özet, PDF (1,061 KB)

Formulation, Optimization & In vitro Evaluation of Pantoprazole Loaded Nanosponges Incorporated Enteric Coated Tablet

Kola MAMATHA*°, Annam Lakshmi DURGA**, Mohammad BAKHATWAR***,
Dr. Asthana Gyati SHILAKARI****, Dr. P. Veeresh BABU*****, Prasanthi BODDU******

* ORCID: 0000-0002-2384-0438, Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Nizampet-Bachupally, India
** ORCID: 0009-0007-1034-2433, Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Nizampet-Bachupally, India
*** ORCID: 0009-0009-9196-3091, Department of pharmaceutics, SNS college of Pharmacy, India
**** ORCID: 0000-0002-2895-2332, Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Nizampet-Bachupally, India
***** ORCID: 0000-0002-2135-3521, Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Nizampet-Bachupally, India
***** ORCID: 0000-0003-2553-3973, Department of Pharmaceutics, GITAM University, Visakhapatnam, India

Sayfalar 675-692, Özet, PDF (1,105 KB)

QbD-Driven Green and White Analytical UPLC–CAD Method for Comprehensive Profiling of Delgocitinib and Its Non-Chromophoric Impurities in Pharmaceutical Formulations

N. Usha RANI*°, S. V. S. R. Krishna BANDARU**, Bhagya Kumar TATAVARTI***,
D. RAMBABU****, U. NAGABABU*****

* ORCID: 0000-0001-5104-516X, Department of FED, PVP Siddhartha Institute of Technology, Vijayawada, Andhra Pradesh-520007, India
** ORCID: 0000-0003-0445-8548, Department of Chemical Engineering, Manipal Institute of Technology, Manipal-576104, India
*** ORCID: 0000-0003-1589-2497, Department of Chemistry, Kakaraparti Bhavanarayana College, Vijayawada, Andhra Pradesh -520001, India
**** ORCID: 0009-0000-3728-1115, Department of Chemistry, KKR & KSR Institute of Technology and Sciences, Guntur, Andhra Pradesh-522017, India
***** ORCID: 0000-0002-3328-9280, Department of Engineering Chemistry, S.R.K.R. Engineering College, West Godavari, Andhra Pradesh-534204, India

Sayfalar 693-712, Özet, PDF (2,752 KB)

Gas Chromatography-Mass Spectrometry-Guided Antioxidant and Multitarget In Silico Analyses of Syzygium polyanthum (Wight) Walp. Compounds Reveal Anti-Inflammatory Potential in Rheumatoid Arthritis

Nurlely NURLELY*, Arief NURROCHMAD**, Sitarina WIDYARINI***,
Khoirunnisa MUSLIMAWATI****, Nanang FAKHRUDIN*****°

* ORCID: 0000-0003-4103-4090, Doctoral Study Programme of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of
Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, South Kalimantan, Indonesia
** ORCID: 0000-0001-7597-2574, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia
*** ORCID: 0000-0003-4461-8454, Department of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
**** ORCID: 0009-0005-3767-8995, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, South Kalimantan, Indonesia
***** ORCID: 0000-0001-7954-9503, Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia; Medicinal Plants and Natural
Products Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia

Sayfalar 713-728, Özet, PDF (3,033 KB)

Preliminary Pharmacopoeia Analysis Studies on Endemic Achillea Species: Achillea sipikorensis Hausskn.& Bornm, and Achillea lycaonica Boiss. & Heldr.

Beyza YILMAZ*, Mehmet TEKİN**, Ceylan DÖNMEZ***°

* ORCID: 0009-0009-4469-9777, Selçuk University, Institute of Health Sciences, Department of Pharmacognosy, Konya, Türkiye
** ORCID: 0000-0002-6504-2223, Trakya University Faculty of Pharmacy, Department of Pharmaceutical Botany, Edirne, Türkiye
*** ORCID: 0000-0002-8005-4425, Selçuk University, Faculty of Pharmacy, Department of Pharmacognosy, Konya, Türkiye

Sayfalar 729-740, Özet, PDF (1,034 KB)

Synthesis and Structural Characterization of Novel Indolin-2-one–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity

Merve ZENGİN*°, Emine Merve YILDIRIM**, Reem K. ARAFA***

* ORCID: 0000-0003-1586-5448, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkiye
** ORCID: 0000-0002-6844-5335, Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkiye
*** ORCID: 0000-0001-7527-1655, Drug Design and Discovery Lab, Zewail City of Science and Technology, Cairo, 12578, Egypt; Biomedical Sciences Program,
University of Science and Technology, Zewail City of Science and Technology, Cairo, 12578, Egypt

Sayfalar 741-754, Özet, PDF (1,833 KB)

Evaluation of Antimicrobial and Biofilm Inhibitory Activities of Flower, Leaf, Seed, and Pulp Extracts of Mahonia aquifolium (Pursh) Nutt.

Kübra ÖĞÜT*°, Pervin SOYER**

* ORCID: 0000-0002-9921-5866, Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Türkiye
** ORCID: 0000-0002-6258-1993, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Türkiye

Sayfalar 755-766, Özet, PDF (261 KB)

In Silico Evaluation of Selective HDAC6 Inhibitors J27820 and J22352 Against Zika Virus Proteins: Molecular Docking and Dynamics Insights

Farid ELBAMTARI*, Etibaria BELGHALIA**, Mhamed ELBOUHI***,
Marwa ALAQARBEH****°, M’barek CHOUKRAD*****, Abdelouahid SBAI******,
Mohammed AZIZ AJANA*******, Tahar LAKHLIFI********, Mohammed BOUACHRINE*********

* ORCID: 0009-0002-2590-2249, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
** ORCID: 0000-0001-6813-3887, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
*** ORCID: 0000-0002-4291-3006, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
**** ORCID: 0000-0002-0879-5077, Applied Science Research Center, Applied Science Private University, Jordan
***** ORCID: 0000-0001-7215-3020, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
****** ORCID: 0000-0002-7140-9853, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
******* ORCID: 0009-0000-9562-418X, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
******** ORCID: 0000-0003-4917-475X, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco
********* ORCID: 0000-0002-8901-047X, Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco

Sayfalar 767-784, Özet, PDF (1,577 KB)

Phytochemical, Taxonomical and Biological Activity Studies on The Endemic Salvia tchihatcheffii Boiss.

Gülçin ÖZTÜRK*, Fatmanur TUNÇ**°, Yavuz Bülent KÖSE***, Gökalp İŞCAN****

* ORCID: 000-0002-5465-2181, Department of Pharmaceutical Botany, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye
** ORCID: 0009-0004-1451-1001, Department of Pharmaceutical Botany, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye
*** ORCID: 0000-0002-3060-7271, Department of Pharmaceutical Botany, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye
**** ORCID: 0000-0003-1210-0490, Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye

Sayfalar 785-802, Özet, PDF (1,784 KB)

Ethanol Extract of Chrysophyllum albidum Stem Bark Elicits Neurobehavioural Alterations via Oxidative Stress, Histological Changes, and Cholinergic Disruption in Wistar Rats

Oluwadamilola Oluwaseun SONIBARE*, Ayomide Adedamola AJIBEWA**º,
Joshua Olumide LEIGH***, Paul Ademola ADELEKE ****, Ifejesu Victoria ADENIYI*****,
Omowumi FEMI-AKINLOSOTU******, Oyindamola Olajumoke ABIODUN*******

* ORCID:0009-0009-1596-8464, Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ibadan, Ibadan, Nigeria
** ORCID: 0009-0002-3243-9555, Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ibadan, Ibadan, Nigeria
*** ORCID:0009-0007-0913-2631, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
**** ORCID: 0000-0002-8466-2807, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
***** ORCID:0009-0003-8319-3505, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
****** ORCID:0000-0002-9933-155X, Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
******* ORCID: 0000-0002-6629-3016, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria

Sayfalar 803-818, Özet, PDF (1,520 KB)

Inosine-Assisted Signal-On Electrochemical Biosensor for Selective Bacterial DNA Detection

Hüseyin Oğuzhan KAYA*, Yamac TEKINTAS**, Hakan KARADENİZ***, Seda Nur TOPKAYA****°

* ORCID: 0000-0002-6529-8325, Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Türkiye; Department of Analytical Chemistry, Faculty of Pharmacy, Izmir
Katip Celebi University, Izmir, Türkiye
** ORCID: 0000-0001-9437-7527, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Izmir Katip Celebi University, Izmir, Türkiye
*** ORCID: 0000-0001-8042-6420, Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Türkiye
**** ORCID: 0000-0002-7816-3155, Izmir Biomedicine and Genome Center, Izmir, Turkey; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Türkiye

Sayfalar 819-838, Özet, PDF (1,489 KB)

Design, Synthesis, and Preliminary Antiproliferative Evaluation of Benzimidazole-1,3,4-oxadiazole Hybrids Showing Preferential Activity in Breast Cancer Cell Lines

Mahmut GOZELLE*°, Şevval YAMAN**, Züleyha ARSLAN***,
Yaprak Dilber ŞİMAY DEMİR****

* ORCID: 0000-0003-0234-6577, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye
** ORCID: 0009-0004-6026-8233, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye
*** ORCID: 0009-0004-1305-8137, Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye
**** ORCID: 0000-0002-8248-0268, Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye

Sayfalar 839-852, Özet, PDF (1,858 KB)

Comparative Evaluation of Extrusion and Emulsification Techniques for Alginate-Based Microencapsulation of Bifidobacterium longum

Pervin SOYER*°, A. Alper ÖZTÜRK**

* ORCID: 0000-0002-6258-1993, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkiye
** ORCID: 0000-0001-9596-0538, Department of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkiye

Sayfalar 853-864, Özet, PDF (265 KB)

Design, Optimization and Performance Profiling of Flexible Nano-vesicular Ciprofloxacin Gel: A Targeted Therapy for Ocular Bacterial Keratitis

Satyam KHAJURIA*, Pritpal Kaur MALHI**, Ramandeep S NARANG***, Karanpreet KAUR****, Dr Jasjeet Kaur NARANG*****°

* ORCID: 0009-0005-3427-3423, School of Pharmacy, Khalsa University, Amritsar, Punjab, India
** ORCID: 0009-0002-7481-8721, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, Punjab, India
*** ORCID: 0000-0002-2036-3883, Department of Oral and Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India
**** ORCID: 0009-0004-6383-8764, School of Pharmacy, Khalsa University, Amritsar, Punjab, India
***** ORCID: 0000-0002-2265-7711, School of Pharmacy, Khalsa University, Amritsar, Punjab, India

Sayfalar 865-898, Özet, PDF (2,534 KB)

Study of Polyphenols, Organic Acids and Radical Scavenging Activity of Red Oak Fruits (Quercus rubra L.)

Olena KONOVALOVA*, Tetiana OMELKOVETS**°, Mariia KALISTA***,
Iryna HURTOVENKO**** , Olha SHCHERBAKOVA*****

* ORCID: 0000-0001-6025-5230, PHEE “Kyiv Medical University” Faculty of Pharmacy, Department of Pharmaceutical and Biological Chemistry, Pharmacognosy, 02099, Kyiv, Ukraine
** ORCID: 0000-0002-1730-1630, PHEE “Kyiv Medical University” Faculty of Pharmacy, Department of Pharmaceutical and Biological Chemistry, Pharmacognosy, 02099, Kyiv, Ukraine
*** ORCID: 0000-0002-2335-5184, National Museum of Natural History of the National Academy of Sciences of Ukraine, 01054, Kyiv, Ukraine; PHEE “Kyiv Medical University” Faculty of
Pharmacy, Department of Pharmaceutical and Biological Chemistry, Pharmacognosy, 02099, Kyiv, Ukraine
**** ORCID: 0000-0003-2442-3406, PHEE “Kyiv Medical University” Faculty of Pharmacy, Department of Pharmaceutical and Biological Chemistry, Pharmacognosy, 02099, Kyiv, Ukraine
***** ORCID: 0000-0001-6601-6476, National Museum of Natural History of the National Academy of Sciences of Ukraine, 01054, Kyiv, Ukraine; PHEE “Kyiv Medical University” Faculty of
Pharmacy, Department of Pharmaceutical and Biological Chemistry, Pharmacognosy, 02099, Kyiv, Ukraine

Sayfalar 899-918, Özet, PDF (744 KB)

Formulation, Scale-Up and Physicochemical Characterization of a Foaming Exfoliating Face and Body Scrub Containing 5% Alpha-Hydroxy Acid

Sibel DİKMEN KÜÇÜK*°

* ORCID: 0000-0002-7852-5128, Faculty of Engineering, Coordination Office of Specialization in Environment and Health Technologies, Duzce University,
Duzce, Turkey

Sayfalar 919-932, Özet, PDF (352 KB)

Retinol and Vitamin C Encapsulation in Liposome for Topical Delivery Using Microfluidization

Yasemin YAĞAN UZUNER*°, Bilge DEMİRCİ**, Neval Sevinç ÖZDEMİR***

* ORCID: 0000-0001-6586-4158, Pharmaceutical Technology Department, Faculty of Pharmacy, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey
** ORCID: 0009-0009-5787-2970, Faculty of Pharmacy, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey
*** ORCID: 000-0003-3416-9755, Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey

Sayfalar 933-950, Özet, PDF (971 KB)

Folded Gastroretentive Bilayer Films Driven by Kollicoat SR 30-D for Sustained Release of Highly Water-Soluble Drugs

Rushikesh WANKHADE*, Dilesh SINGHAVI**°, Yogeeta MUDE***,
Nilesh KARANDE****, Rajendra GANJIWALE*****

* ORCID: 0009-0004-4812-7868, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India
** ORCID: 0000-0002-2544-7226, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India
*** ORCID: 0009-0009-5938-6706, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India
**** ORCID: 0000-0002-3657-2364, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India
***** ORCID: 0000-0002-5707-7434, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India

Sayfalar 951-966, Özet, PDF (673 KB)

Evaluation of Cytotoxic, Genotoxic and Apoptotic Effects of Turkish Sea Buckthorn (Hippophae rhamnoides L.) Fruit Extracts in Human Glioblastoma and Melanoma Cell Lines

Duygu SEVİM-TATAR*°, Jülide SECERLİ**, Merve GÜDÜL BACANLI***, ****

* ORCID: 0000-0003-3987-2466, Department of Pharmacognosy, Gülhane Faculty of Pharmacy, University of Health Sciences Turkey, Ankara, Türkiye
** ORCID: 0000-0002-4875-2266, Department of Pharmaceutical Toxicology, Gülhane Faculty of Pharmacy, University of Health Sciences Turkey, Ankara, Türkiye
*** ORCID: 0000-0001-8757-0572, Department of Pharmaceutical Toxicology, Gülhane Faculty of Pharmacy, University of Health Sciences Turkey, Ankara, Türkiye
**** ORCID: 0000-0001-8757-0572, Turkish Vaccine Institute, Health Institutes of Türkiye, Aziz Sancar Research Center, Ankara, Türkiye

Sayfalar 967-980, Özet, PDF (1,326 KB)

Examining the Mediating Role of Entrepreneurial Intention in the Relationship Between General Self-Efficacy and Career Stress Among Pharmacy Students

Yağmur ÖZKAYA*°, Gülden HAKVERDİ**

* ORCID: 0000-0003-2937-0366, Department of Pharmacy Management, Faculty of Pharmacy, Erzincan Binali Yildirim University, Erzincan, Turkey
** ORCID: 0000-0002-8078-0451, Department of Biostatistics, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey

Sayfalar 981-992, Özet, PDF (160 KB)

DART-MS: A Potential Ambient Ionisation Strategy That Revolutionises the Mass Spectroscopic Applications

Ceema MATHEW*°, Jahnavi BEJJANKİ**, Shashikala METRİ***,
Anumolu Durga Pani KUMAR****, Kaurna DEVI BARLA*****

* ORCID: 0000-0001-5655-8263, Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, 500090, India
** ORCID: 0009-0002-5549-9323, Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, 500090, India
*** ORCID: 0000-0002-2072-6947, Department of Pharmacognosy, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, 500090, India
**** ORCID: 0000-0001-5010-7488, Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, 500090, India
***** ORCID: 0000-0002-5746-4346, Department of Pharmaceutical Chemistry, Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, 500090, India

Sayfalar 933-1018, Özet, PDF (1,320 KB)

Innovative Approaches to Combating Antibiotic Resistance: The Role of Metal Oxide Nanoparticles

Gülen Melike DEMİRBOLAT*, Müjde ERYILMAZ**°, Bindia JUNEJO***

* ORCID: 0000-0001-5621-5818, Department of Pharmaceutical Technology, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye
** ORCID: 0000-0003-3760-1996, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye
*** ORCID: 0000-0002-9997-6913, Food Quality & Safety Research Institute, PARC-Southern Zone Agricultural Research Centre, Karachi 75270, Pakistan

Sayfalar 1019-1040, Özet, PDF (858 KB)

The Pharmacological and Chemical Profile of Vorinostat (SAHA): A Comprehensive Review

Zain ORFALI*, Zehra ARSLAN**, Oya Bozdağ DÜNDAR***°

* ORCID: 0000-0002-1810-7442, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandogan, Ankara, Turkey
** ORCID: 0000-0001-9169-667X, Ankara University, Institute of Health Sciences, 06110 Dışkapı, Ankara, Turkey
*** ORCID: 0000-0002-2240-8854, Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandogan, Ankara, Turkey

Sayfalar 1041-1058, Özet, PDF (835 KB)

2-Sulfanylidene-2,3-dihydropyridopyrimidin-4(1H)-one Derivatives: Synthesis, Reactions and Biological Activities

Ferhat GÜNEŞ*,**, Özge KUYRUKÇU ÖZTÜRK***, Yasemin DÜNDAR****°

* ORCID: 0000-0001-6791-9538, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Türkiye
** ORCID: 0000-0001-6791-9538, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye
*** ORCID: 0000-0002-5147-7015, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye
**** ORCID: 0000-0002-8250-7096, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Türkiye

Sayfalar 1059-1086, Özet, PDF (959 KB)

Towards Predictive, Preventive, and Participatory Care: The Promise of Personalized Medicine

Janhavi J. PATIL*, Diya H. AGA**, Sneha J. YADAV***, Pooja S. MANE****,
Nuha I. KHAMKAR*****, Dhanashree P. SANAP******°

* ORCID: 0009-0000-4840-6358, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
** ORCID: 0009-0001-3358-2735, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
*** ORCID: 0009-0008-8793-0927, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
**** ORCID: 0009-0003-6468-4050, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
***** ORCID: 0009-0000-9764-3157, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India
****** ORCID: 0000-0002-4794-7598, Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai – 400614, Maharashtra, India

Sayfalar 1087-1112, Özet, PDF (683 KB)

Role of Trimethylamine N-Oxide in Atherosclerosis: Inflammation, ER Stress and Beyond

Zeliha RUMANLI*, Aysun HACIŞEVKİ**°

* ORCID: 0000-0003-0550-6281, University of Health Sciences, Gülhane Faculty of Pharmacy, Department of Pharmacology, Ankara, Türkiye
** ORCID: 0000-0002-3844-5772, Gazi University, Faculty of Pharmacy, Department of Biochemistry, and Gazi University, Institute of Health Sciences, Sports
Pharmacy Program, Ankara, Türkiye.

Sayfalar 1113-1130, Özet, PDF (171 KB)

Harnessing Artificial Intelligence for Microneedle-Mediated Transdermal Delivery of Stimulus-Responsive Nanocarriers: A New Frontier in Personalized Cancer Immunotherapy

Komang Dian Aditya PUTRA*, Andayana Puspitasari GANI**, Akhmad Kharis NUGROHO***°

* ORCID: 0000-0003-1652-8339, Master in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta, 55281, Indonesia
** ORCID: 0000-0002-0775-8127, Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia
*** ORCID: 0000-0003-4277-5413, Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia

Sayfalar 1131-1158, Özet, PDF (242 KB)

Effects of Ficus carica and Its Compounds on Smooth Muscle Contractility

Sadettin DEMIREL*°, Ipek Nazli SINAG**

* ORCID: 0000-0002-3629-5344, Department of Physiology, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye
** ORCID: 0009-0008-8810-9276, Department of Physiology, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye

Sayfalar 1159-1190, Özet, PDF (1,111 KB)